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• W2320061024 abstract "Increased miR-222 levels are associated with a poor prognosis in patients with bladder cancer. However, the role of miR-222 remains unclear. In the present study, we found that miR-222 enhanced the proliferation of both the T24 and the 5637 bladder cancer cell lines. Overexpression of miR-222 attenuated cisplatin-induced cell death in bladder cancer cells. miR-222 activated the Akt/mTOR pathway and inhibited cisplatin-induced autophagy in bladder cancer cells by directly targeting protein phosphatase 2A subunit B (PPP2R2A). Blocking the activation of Akt with LY294002 or mTOR with rapamycin significantly prevented miR-222-induced proliferation and restored the sensitivity of bladder cancer cells to cisplatin. These findings demonstrate that miR-222 modulates the PPP2R2A/Akt/mTOR axis and thus plays a critical role in regulating proliferation and chemotherapeutic drug resistance. Therefore, miR-222 may be a novel therapeutic target for bladder cancer." @default.
• W2320061024 created "2016-06-24" @default.
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• W2320061024 date "2016-01-22" @default.
• W2320061024 modified "2023-10-13" @default.
• W2320061024 title "miR‐222 attenuates cisplatin‐induced cell death by targeting the <scp>PPP</scp> 2R2A/Akt/ <scp>mTOR</scp> Axis in bladder cancer cells" @default.
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• W2320061024 doi "https://doi.org/10.1111/jcmm.12760" @default.
• W2320061024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4759461" @default.
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