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• W2320101488 abstract "<h3>Objective</h3> International guidelines recommend a compression to ventilation (C:V) ratio of 3:1 in neonates, and 15:2 for other paediatric age groups. The authors aimed to compare these two C:V ratios in a neonatal swine model of cardiac arrest following asphyxia. <h3>Design</h3> Experimental animal study. <h3>Setting</h3> Facility for animal research. <h3>Subjects</h3> 22 newborn pigs (age 12–36 h, weight 2.0–2.7 kg). <h3>Interventions</h3> Progressive asphyxia until asystole. Animals were randomised to receive C:V 3:1 (n=11) or 15:2 (n=11). <h3>Main outcome measures</h3> Return of spontaneous circulation (ROSC) was defined as a heart rate ≥100 bpm. Also of interest were haemodynamic parameters, cerebral and systemic oxygen saturation and the proinflammatory cytokine interleukin-1β (IL-1β). <h3>Results</h3> Two animals in each group did not achieve ROSC. Mean (SD) increase in diastolic blood pressure (DBP; mm Hg) during compression cycles was significantly higher at a C:V ratio of 15:2 than 3:1 (7.1 (2.8) vs 4.8 (2.6)). Median time (IQR) to ROSC for the 3:1 group was 150 (140–180) s, and 195 (145–358) s for the 15:2 group. There were no significant differences in the temporal changes in haemodynamic parameters or oxygen saturation indices between the groups. IL-1β levels in cerebrospinal and bronchoalveolar lavage fluid was comparable between the groups. <h3>Conclusion</h3> In neonatal pigs with asphyxia-induced cardiac arrest, the response to a C:V ratio of 15:2 is not better than the response to a C:V ratio of 3:1 despite better generation of DBP during resuscitation." @default.
• W2320101488 created "2016-06-24" @default.
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• W2320101488 date "2011-03-10" @default.
• W2320101488 modified "2023-10-16" @default.
• W2320101488 title "Return of spontaneous circulation with a compression:ventilation ratio of 15:2 versus 3:1 in newborn pigs with cardiac arrest due to asphyxia" @default.
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• W2320101488 doi "https://doi.org/10.1136/adc.2010.200386" @default.
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