Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320121145> ?p ?o ?g. }
- W2320121145 endingPage "692" @default.
- W2320121145 startingPage "685" @default.
- W2320121145 abstract "Gemtuzumab Ozogamicin (GO, CMA-676) is a monoclonal antibody against the cellular surface antigen CD33 conjugated with the cytotoxic antibiotic calicheamicin. In the beginning of 2000 it obtained US Food and Drug Administration approval for the treatment of refractory acute myeloid leukemia (AML) expressing CD33 in patients older than 60 years who are not candidates for other chemotherapy. After ligation with the CD33 on the cell surface, GO is internalized and hydrolyzed. Its two components are released into the cytoplasm and calicheamicin enters the nucleus where it associates with the DNA, causing double helix breaks and finally cell death. GO is in general well tolerated. The most frequent adverse effect observed is myelotoxicity, with prolonged neutropenia and thrombocytopenia. Veno-occlusive disease of the liver is a less frequent but severe adverse effect. A phase II study points towards a percentage of overall hematologic response around 30% in the setting of refractory or relapsed disease. Future phase III trials will show the most suitable place of GO in the treatment of AML." @default.
- W2320121145 created "2016-06-24" @default.
- W2320121145 creator A5038353919 @default.
- W2320121145 date "2002-08-01" @default.
- W2320121145 modified "2023-09-26" @default.
- W2320121145 title "Gemtuzumab Ozogamicin (CMA-676, Mylotarg) for the treatment of CD33+ acute myeloid leukemia" @default.
- W2320121145 cites W147398146 @default.
- W2320121145 cites W1520015039 @default.
- W2320121145 cites W1842764967 @default.
- W2320121145 cites W1970497431 @default.
- W2320121145 cites W1983266647 @default.
- W2320121145 cites W1990726946 @default.
- W2320121145 cites W1992335590 @default.
- W2320121145 cites W1993078113 @default.
- W2320121145 cites W2004052226 @default.
- W2320121145 cites W2006498624 @default.
- W2320121145 cites W2008977792 @default.
- W2320121145 cites W2011711699 @default.
- W2320121145 cites W2013194808 @default.
- W2320121145 cites W2015498864 @default.
- W2320121145 cites W2025545798 @default.
- W2320121145 cites W2030522563 @default.
- W2320121145 cites W2031008930 @default.
- W2320121145 cites W2039223287 @default.
- W2320121145 cites W2040758757 @default.
- W2320121145 cites W2058418701 @default.
- W2320121145 cites W2060576173 @default.
- W2320121145 cites W2067766312 @default.
- W2320121145 cites W2068070915 @default.
- W2320121145 cites W2076106584 @default.
- W2320121145 cites W2082635925 @default.
- W2320121145 cites W2092622883 @default.
- W2320121145 cites W2104800170 @default.
- W2320121145 cites W2107015590 @default.
- W2320121145 cites W2107170234 @default.
- W2320121145 cites W2117625745 @default.
- W2320121145 cites W2159533632 @default.
- W2320121145 cites W2160835020 @default.
- W2320121145 cites W2169746118 @default.
- W2320121145 cites W2222638000 @default.
- W2320121145 cites W2223333564 @default.
- W2320121145 cites W2326487196 @default.
- W2320121145 cites W2326561055 @default.
- W2320121145 cites W2327387659 @default.
- W2320121145 cites W2335612101 @default.
- W2320121145 cites W253073608 @default.
- W2320121145 cites W3082443879 @default.
- W2320121145 cites W3190509665 @default.
- W2320121145 cites W326932590 @default.
- W2320121145 cites W4248990922 @default.
- W2320121145 cites W4256395723 @default.
- W2320121145 doi "https://doi.org/10.1097/00001813-200208000-00002" @default.
- W2320121145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12187324" @default.
- W2320121145 hasPublicationYear "2002" @default.
- W2320121145 type Work @default.
- W2320121145 sameAs 2320121145 @default.
- W2320121145 citedByCount "28" @default.
- W2320121145 countsByYear W23201211452014 @default.
- W2320121145 countsByYear W23201211452015 @default.
- W2320121145 countsByYear W23201211452016 @default.
- W2320121145 countsByYear W23201211452017 @default.
- W2320121145 countsByYear W23201211452020 @default.
- W2320121145 countsByYear W23201211452021 @default.
- W2320121145 countsByYear W23201211452022 @default.
- W2320121145 crossrefType "journal-article" @default.
- W2320121145 hasAuthorship W2320121145A5038353919 @default.
- W2320121145 hasConcept C10205521 @default.
- W2320121145 hasConcept C126322002 @default.
- W2320121145 hasConcept C143998085 @default.
- W2320121145 hasConcept C176290653 @default.
- W2320121145 hasConcept C197934379 @default.
- W2320121145 hasConcept C203014093 @default.
- W2320121145 hasConcept C2778245361 @default.
- W2320121145 hasConcept C2778461978 @default.
- W2320121145 hasConcept C2778623314 @default.
- W2320121145 hasConcept C2778729363 @default.
- W2320121145 hasConcept C28328180 @default.
- W2320121145 hasConcept C502942594 @default.
- W2320121145 hasConcept C54355233 @default.
- W2320121145 hasConcept C71924100 @default.
- W2320121145 hasConcept C86803240 @default.
- W2320121145 hasConcept C98274493 @default.
- W2320121145 hasConceptScore W2320121145C10205521 @default.
- W2320121145 hasConceptScore W2320121145C126322002 @default.
- W2320121145 hasConceptScore W2320121145C143998085 @default.
- W2320121145 hasConceptScore W2320121145C176290653 @default.
- W2320121145 hasConceptScore W2320121145C197934379 @default.
- W2320121145 hasConceptScore W2320121145C203014093 @default.
- W2320121145 hasConceptScore W2320121145C2778245361 @default.
- W2320121145 hasConceptScore W2320121145C2778461978 @default.
- W2320121145 hasConceptScore W2320121145C2778623314 @default.
- W2320121145 hasConceptScore W2320121145C2778729363 @default.
- W2320121145 hasConceptScore W2320121145C28328180 @default.
- W2320121145 hasConceptScore W2320121145C502942594 @default.
- W2320121145 hasConceptScore W2320121145C54355233 @default.
- W2320121145 hasConceptScore W2320121145C71924100 @default.
- W2320121145 hasConceptScore W2320121145C86803240 @default.
- W2320121145 hasConceptScore W2320121145C98274493 @default.