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• W2320145239 abstract "Five new steroidal glycosides (1–5) and nine known compounds were isolated from Solanum violaceum. Indiosides G (1) and H (2) are spirostene saponins with an iso-type F ring, indioside I (3) is a spirostane saponin, and indiosides J (4) and K (5) are unusual furostanol saponins with a deformed F ring. These structures represent rare naturally occurring steroidal skeletons. The structures of the new compounds were elucidated using 1D and 2D spectroscopic techniques and acid hydrolysis. Compounds 2, 3, and 7–9 exhibited cytotoxic activity against six human cancer cell lines (HepG2, Hep3B, A549, Ca9-22, MDA-MB-231, and MCF-7) with IC50 values of 1.83–8.04 μg/mL. Steroidal saponins 3, 8, and 9 showed inhibitory effects on superoxide anion generation with IC50 values of 2.84 ± 0.18, 0.62 ± 0.03, and 1.62 ± 0.59 μg/mL, respectively. Saponins 8 and 9 also inhibited elastase release with IC50 values of 111.05 ± 7.37 and 4.04 ± 0.51 μg/mL, respectively. Structure–activity relationship correlations of these compounds with respect to cytotoxic and anti-inflammatory effects are discussed." @default.
• W2320145239 created "2016-06-24" @default.
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• W2320145239 date "2012-03-13" @default.
• W2320145239 modified "2023-09-26" @default.
• W2320145239 title "Indiosides G–K: Steroidal Glycosides with Cytotoxic and Anti-inflammatory Activities from <i>Solanum violaceum</i>" @default.
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• W2320145239 doi "https://doi.org/10.1021/np200877u" @default.
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