FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320149013> ?p ?o ?g. }

• W2320149013 abstract "Abstract The ATP-binding cassette (ABC) transporters represent a superfamily of proteins that have important physiological roles in both prokaryotes and eukaryotes. In insects, ABC transporters have previously been implicated in insecticide resistance. The 91-R strain of Drosophila melanogaster has been intensely selected with DDT over six decades. A recent selective sweeps analysis of 91-R implicated the potential role of MDR49 , an ABC transporter, in DDT resistance, however, to date the details of how MDR49 may play a role in resistance have not been elucidated. In this study, we investigated the impact of structural changes and an alternative splicing event in MDR49 on DDT-resistance in 91-R , as compared to the DDT susceptible strain 91-C . We observed three amino acid differences in MDR49 when 91-R was compared with 91-C , and only one isoform (MDR49B) was implicated in DDT resistance. A transgenic Drosophila strain containing the 91-R - MDR49B isoform had a significantly higher LD 50 value as compared to the 91-C - MDR49B isoform at the early time points (6 h to 12 h) during DDT exposure. Our data support the hypothesis that the MDR49B isoform, with three amino acid mutations, plays a role in the early aspects of DDT resistance in 91-R ." @default.
• W2320149013 created "2016-06-24" @default.
• W2320149013 creator A5049936208 @default.
• W2320149013 creator A5052361629 @default.
• W2320149013 creator A5077402038 @default.
• W2320149013 creator A5090630481 @default.
• W2320149013 date "2016-03-22" @default.
• W2320149013 modified "2023-09-27" @default.
• W2320149013 title "Splice form variant and amino acid changes in MDR49 confers DDT resistance in transgenic Drosophila" @default.
• W2320149013 cites W1583430045 @default.
• W2320149013 cites W1886638126 @default.
• W2320149013 cites W1908587496 @default.
• W2320149013 cites W1980147119 @default.
• W2320149013 cites W1980651502 @default.
• W2320149013 cites W1989778165 @default.
• W2320149013 cites W1997394341 @default.
• W2320149013 cites W2006368030 @default.
• W2320149013 cites W2010404725 @default.
• W2320149013 cites W2017956827 @default.
• W2320149013 cites W2017980106 @default.
• W2320149013 cites W2019598092 @default.
• W2320149013 cites W2025441649 @default.
• W2320149013 cites W2038848072 @default.
• W2320149013 cites W2041365345 @default.
• W2320149013 cites W2046271904 @default.
• W2320149013 cites W2055927160 @default.
• W2320149013 cites W2057128621 @default.
• W2320149013 cites W2070313237 @default.
• W2320149013 cites W2073506866 @default.
• W2320149013 cites W2077986322 @default.
• W2320149013 cites W2080287948 @default.
• W2320149013 cites W2085861515 @default.
• W2320149013 cites W2087350092 @default.
• W2320149013 cites W2088228641 @default.
• W2320149013 cites W2091399559 @default.
• W2320149013 cites W2092247420 @default.
• W2320149013 cites W2092987873 @default.
• W2320149013 cites W2098086227 @default.
• W2320149013 cites W2104076756 @default.
• W2320149013 cites W2128454622 @default.
• W2320149013 cites W2144901789 @default.
• W2320149013 cites W2147300987 @default.
• W2320149013 cites W2148279352 @default.
• W2320149013 cites W2162097287 @default.
• W2320149013 cites W2166364123 @default.
• W2320149013 cites W2271003837 @default.
• W2320149013 cites W2328101021 @default.
• W2320149013 cites W2469213537 @default.
• W2320149013 cites W4205389445 @default.
• W2320149013 cites W4253600200 @default.
• W2320149013 cites W942297970 @default.
• W2320149013 doi "https://doi.org/10.1038/srep23355" @default.
• W2320149013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4802207" @default.
• W2320149013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27003579" @default.
• W2320149013 hasPublicationYear "2016" @default.
• W2320149013 type Work @default.
• W2320149013 sameAs 2320149013 @default.
• W2320149013 citedByCount "30" @default.
• W2320149013 countsByYear W23201490132016 @default.
• W2320149013 countsByYear W23201490132017 @default.
• W2320149013 countsByYear W23201490132018 @default.
• W2320149013 countsByYear W23201490132019 @default.
• W2320149013 countsByYear W23201490132020 @default.
• W2320149013 countsByYear W23201490132021 @default.
• W2320149013 countsByYear W23201490132022 @default.
• W2320149013 countsByYear W23201490132023 @default.
• W2320149013 crossrefType "journal-article" @default.
• W2320149013 hasAuthorship W2320149013A5049936208 @default.
• W2320149013 hasAuthorship W2320149013A5052361629 @default.
• W2320149013 hasAuthorship W2320149013A5077402038 @default.
• W2320149013 hasAuthorship W2320149013A5090630481 @default.
• W2320149013 hasBestOaLocation W23201490131 @default.
• W2320149013 hasConcept C102230213 @default.
• W2320149013 hasConcept C104317684 @default.
• W2320149013 hasConcept C105702510 @default.
• W2320149013 hasConcept C149011108 @default.
• W2320149013 hasConcept C194583182 @default.
• W2320149013 hasConcept C2776041557 @default.
• W2320149013 hasConcept C2778022156 @default.
• W2320149013 hasConcept C2780104201 @default.
• W2320149013 hasConcept C2780989783 @default.
• W2320149013 hasConcept C44312359 @default.
• W2320149013 hasConcept C515207424 @default.
• W2320149013 hasConcept C53345823 @default.
• W2320149013 hasConcept C54355233 @default.
• W2320149013 hasConcept C55493867 @default.
• W2320149013 hasConcept C86803240 @default.
• W2320149013 hasConceptScore W2320149013C102230213 @default.
• W2320149013 hasConceptScore W2320149013C104317684 @default.
• W2320149013 hasConceptScore W2320149013C105702510 @default.
• W2320149013 hasConceptScore W2320149013C149011108 @default.
• W2320149013 hasConceptScore W2320149013C194583182 @default.
• W2320149013 hasConceptScore W2320149013C2776041557 @default.
• W2320149013 hasConceptScore W2320149013C2778022156 @default.
• W2320149013 hasConceptScore W2320149013C2780104201 @default.
• W2320149013 hasConceptScore W2320149013C2780989783 @default.
• W2320149013 hasConceptScore W2320149013C44312359 @default.
• W2320149013 hasConceptScore W2320149013C515207424 @default.
• W2320149013 hasConceptScore W2320149013C53345823 @default.
• W2320149013 hasConceptScore W2320149013C54355233 @default.

• next