FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320151632> ?p ?o ?g. }

• W2320151632 endingPage "402" @default.
• W2320151632 startingPage "395" @default.
• W2320151632 abstract "HIV-infected patients who fail to reconstitute their CD4 T-cell counts during suppressive antiretroviral therapy (ART) have increased risk of both AIDS-related and non-AIDS-related morbidity and mortality. Improved understanding of immunological nonresponse (INR) is necessary to enable earlier clinical intervention.In a cohort of 112 HIV-infected patients starting ART, we performed a serial analysis of 32 plasma-soluble markers, assessed by multiplex cytokine and enzyme immunoassay. Samples were drawn pre-ART and during the first 3 years of treatment, with a final observation time of 8.4 years (interquartile range, 7.0-10.7 years) on ART. Long-term INR (LT-INR) was defined as failure to reach a CD4 T-cell count >350 cells per microliter. Marker stability was evaluated by parallel analysis of samples from ART-naïve and HIV-seronegative controls.Baseline CD4 T-cell counts predicted subsequent LT-INR (n = 15) [odds ratio, 1.10 (95% confidence interval: 1.01 to 1.19) pr. 10 cells/μL reduction in CD4 count, P = 0.030] in the cohort as a whole, but not in patients with baseline CD4 counts <200 cells per microliter (n = 78). LT-INR was best characterized by elevated plasma levels of the CC chemokine macrophage inflammatory protein 1β (MIP-1β), both at baseline (pre-ART) and during ART. In patients with baseline CD4 counts <200 cells per microliter, baseline MIP-1β predicted LT-INR [odds ratio 1.23 (95% confidence interval: 1.02 to 1.47) per 10 pg/mL increase in MIP-1β, P = 0.029].Elevated pre-ART levels of MIP-1β identified LT-INR patients who started ART at CD4 counts <200. INR was characterized by persistently high MIP-1β during suppressive ART. Thus, MIP-1β may be of use for early identification of LT-INR." @default.
• W2320151632 created "2016-06-24" @default.
• W2320151632 creator A5024469667 @default.
• W2320151632 creator A5034080390 @default.
• W2320151632 creator A5034439136 @default.
• W2320151632 creator A5039625009 @default.
• W2320151632 creator A5052524987 @default.
• W2320151632 creator A5065042459 @default.
• W2320151632 creator A5076836210 @default.
• W2320151632 creator A5078524395 @default.
• W2320151632 creator A5083687567 @default.
• W2320151632 date "2015-08-01" @default.
• W2320151632 modified "2023-10-18" @default.
• W2320151632 title "High MIP-1β Levels in Plasma Predict Long-Term Immunological Nonresponse to Suppressive Antiretroviral Therapy in HIV Infection" @default.
• W2320151632 cites W1488316909 @default.
• W2320151632 cites W1573558157 @default.
• W2320151632 cites W1688738816 @default.
• W2320151632 cites W1952272382 @default.
• W2320151632 cites W1963759891 @default.
• W2320151632 cites W1965538807 @default.
• W2320151632 cites W1965914277 @default.
• W2320151632 cites W1967974256 @default.
• W2320151632 cites W1972248422 @default.
• W2320151632 cites W1975932520 @default.
• W2320151632 cites W1981582426 @default.
• W2320151632 cites W1984776683 @default.
• W2320151632 cites W1984811742 @default.
• W2320151632 cites W1985722970 @default.
• W2320151632 cites W1989202421 @default.
• W2320151632 cites W1990260535 @default.
• W2320151632 cites W1995006704 @default.
• W2320151632 cites W1999417836 @default.
• W2320151632 cites W2003071165 @default.
• W2320151632 cites W2003382092 @default.
• W2320151632 cites W2004937435 @default.
• W2320151632 cites W2005218441 @default.
• W2320151632 cites W2013104735 @default.
• W2320151632 cites W2016365939 @default.
• W2320151632 cites W2046044391 @default.
• W2320151632 cites W2046781531 @default.
• W2320151632 cites W2050724772 @default.
• W2320151632 cites W2058658618 @default.
• W2320151632 cites W2060901160 @default.
• W2320151632 cites W2076579763 @default.
• W2320151632 cites W2082617054 @default.
• W2320151632 cites W2089568674 @default.
• W2320151632 cites W2094791689 @default.
• W2320151632 cites W2104838062 @default.
• W2320151632 cites W2106164053 @default.
• W2320151632 cites W2113422652 @default.
• W2320151632 cites W2121217556 @default.
• W2320151632 cites W2125726664 @default.
• W2320151632 cites W2130397839 @default.
• W2320151632 cites W2140606947 @default.
• W2320151632 cites W2141457436 @default.
• W2320151632 cites W2141911926 @default.
• W2320151632 cites W2144361427 @default.
• W2320151632 cites W2148750104 @default.
• W2320151632 cites W2156197349 @default.
• W2320151632 cites W2160132227 @default.
• W2320151632 cites W2166535756 @default.
• W2320151632 cites W2329393410 @default.
• W2320151632 cites W4312464950 @default.
• W2320151632 doi "https://doi.org/10.1097/qai.0000000000000617" @default.
• W2320151632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26115437" @default.
• W2320151632 hasPublicationYear "2015" @default.
• W2320151632 type Work @default.
• W2320151632 sameAs 2320151632 @default.
• W2320151632 citedByCount "6" @default.
• W2320151632 countsByYear W23201516322016 @default.
• W2320151632 countsByYear W23201516322017 @default.
• W2320151632 countsByYear W23201516322020 @default.
• W2320151632 countsByYear W23201516322021 @default.
• W2320151632 countsByYear W23201516322022 @default.
• W2320151632 crossrefType "journal-article" @default.
• W2320151632 hasAuthorship W2320151632A5024469667 @default.
• W2320151632 hasAuthorship W2320151632A5034080390 @default.
• W2320151632 hasAuthorship W2320151632A5034439136 @default.
• W2320151632 hasAuthorship W2320151632A5039625009 @default.
• W2320151632 hasAuthorship W2320151632A5052524987 @default.
• W2320151632 hasAuthorship W2320151632A5065042459 @default.
• W2320151632 hasAuthorship W2320151632A5076836210 @default.
• W2320151632 hasAuthorship W2320151632A5078524395 @default.
• W2320151632 hasAuthorship W2320151632A5083687567 @default.
• W2320151632 hasBestOaLocation W23201516321 @default.
• W2320151632 hasConcept C119060515 @default.
• W2320151632 hasConcept C126322002 @default.
• W2320151632 hasConcept C142462285 @default.
• W2320151632 hasConcept C156957248 @default.
• W2320151632 hasConcept C203014093 @default.
• W2320151632 hasConcept C2993143319 @default.
• W2320151632 hasConcept C3013748606 @default.
• W2320151632 hasConcept C44249647 @default.
• W2320151632 hasConcept C71924100 @default.
• W2320151632 hasConcept C72563966 @default.
• W2320151632 hasConcept C90924648 @default.
• W2320151632 hasConceptScore W2320151632C119060515 @default.
• W2320151632 hasConceptScore W2320151632C126322002 @default.

• next