FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320153362> ?p ?o ?g. }

• W2320153362 endingPage "808" @default.
• W2320153362 startingPage "799" @default.
• W2320153362 abstract "Summary Effects of α1-adrenoceptor stimulation on the action potential shortening produced by K+ channel openers (KCOs) or hypoxia and on the ATP-sensitive K+ current (IK.ATP) activated by KCOs were examined in guinea-pig ventricular cells by using conventional microelectrode and patch-clamp techniques. In papillary muscles, nicorandil (1 mM) or cromakalim (30 μM) markedly shortened the action potential duration (APD) (to 51 ± 2% and 40 ± 5% of each control value). Addition of 100 μM methoxamine, an α1-adrenoceptor agonist, partially but significantly reversed the KCOs-induced APD shortening (to 69 ± 3% and 50 ± 4% of each control value). The APD-prolonging effect of methoxamine was antagonized by 1 μM prazosin (α1-antagonist) and 100 nM WB4101 (α1A-antagonist) but not by 10 μM chloroethylclonidine (α1B-antagonist). In papillary muscles exposed to a hypoxic, glucose-free solution, APD declined gradually. In the presence of 100 μM methoxamine or 10 μM glibenclamide, the hypoxia-induced action potential shortening was significantly inhibited. In single ventricular myocytes, the KCOs increased a steady-state outward current that was abolished by glibenclamide (1 μM), thereby suggesting that these KCOs activate IK.ATP. Methoxamine (100 μM) significantly inhibited the nicorandil-induced IK.ATP by 18 ± 5% and the cromakalim-induced IK.ATP by 16 ± 2%. 4β-Phorbol 12-myristate 13-acetate (100 nM), a protein kinase C activator, failed to mimic the α1-adrenoceptor-mediated inhibition of the nicorandil-induced outward current. Staurosporine (30 nM), a protein kinase C inhibitor, also failed to affect the partial inhibition of IK.ATP by methoxamine. Neither intracellular loading of heparin (100 μg/ml), an inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ release inhibitor, nor IP3 (20 μM) plus inositol 1,3,4,5-tetrakisphosphate (IP4 5 μM) could affect the inhibitory action of methoxamine. In conclusion, α1A-adrenergic stimulation partially inhibits IK.ATP in cardiac cells. Neither protein kinase C activation nor IP3 formation appears to be involved in the partial inhibition of IK.ATP. The α1A-adrenoceptor-mediated inhibition of IK.ATP may be deleterious for ischemic myocardium and partly offset the cardioprotective effect of KCOs because attenuation of action potential shortening may potentially increase Ca2+ influx in ischemic cells." @default.
• W2320153362 created "2016-06-24" @default.
• W2320153362 creator A5011906577 @default.
• W2320153362 creator A5027768055 @default.
• W2320153362 creator A5029227166 @default.
• W2320153362 creator A5053201616 @default.
• W2320153362 creator A5086966285 @default.
• W2320153362 date "1996-12-01" @default.
• W2320153362 modified "2023-10-01" @default.
• W2320153362 title "α1-Adrenoceptor Stimulation Partially Inhibits ATP-Sensitive K+ Current in Guinea Pig Ventricular Cells: Attenuation of the Action Potential Shortening Induced by Hypoxia and K+ Channel Openers" @default.
• W2320153362 cites W1967353223 @default.
• W2320153362 cites W1969513630 @default.
• W2320153362 cites W1978468222 @default.
• W2320153362 cites W1980374824 @default.
• W2320153362 cites W2018473024 @default.
• W2320153362 cites W2023983581 @default.
• W2320153362 cites W2030998095 @default.
• W2320153362 cites W2033168194 @default.
• W2320153362 cites W2035823879 @default.
• W2320153362 cites W2037356405 @default.
• W2320153362 cites W2038159880 @default.
• W2320153362 cites W2045498839 @default.
• W2320153362 cites W2048701510 @default.
• W2320153362 cites W2057994986 @default.
• W2320153362 cites W2058461797 @default.
• W2320153362 cites W2064953660 @default.
• W2320153362 cites W2072598390 @default.
• W2320153362 cites W2078081709 @default.
• W2320153362 cites W2079265669 @default.
• W2320153362 cites W2083707111 @default.
• W2320153362 cites W2088462035 @default.
• W2320153362 cites W2116963442 @default.
• W2320153362 cites W2136147069 @default.
• W2320153362 cites W2144899729 @default.
• W2320153362 cites W2153475498 @default.
• W2320153362 cites W2170679542 @default.
• W2320153362 cites W2269172808 @default.
• W2320153362 doi "https://doi.org/10.1097/00005344-199612000-00010" @default.
• W2320153362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8961078" @default.
• W2320153362 hasPublicationYear "1996" @default.
• W2320153362 type Work @default.
• W2320153362 sameAs 2320153362 @default.
• W2320153362 citedByCount "13" @default.
• W2320153362 countsByYear W23201533622016 @default.
• W2320153362 countsByYear W23201533622017 @default.
• W2320153362 crossrefType "journal-article" @default.
• W2320153362 hasAuthorship W2320153362A5011906577 @default.
• W2320153362 hasAuthorship W2320153362A5027768055 @default.
• W2320153362 hasAuthorship W2320153362A5029227166 @default.
• W2320153362 hasAuthorship W2320153362A5053201616 @default.
• W2320153362 hasAuthorship W2320153362A5086966285 @default.
• W2320153362 hasBestOaLocation W23201533621 @default.
• W2320153362 hasConcept C12554922 @default.
• W2320153362 hasConcept C126322002 @default.
• W2320153362 hasConcept C134018914 @default.
• W2320153362 hasConcept C170493617 @default.
• W2320153362 hasConcept C184235292 @default.
• W2320153362 hasConcept C185592680 @default.
• W2320153362 hasConcept C195794163 @default.
• W2320153362 hasConcept C24998067 @default.
• W2320153362 hasConcept C2775984225 @default.
• W2320153362 hasConcept C2776885963 @default.
• W2320153362 hasConcept C2778902376 @default.
• W2320153362 hasConcept C2778938600 @default.
• W2320153362 hasConcept C2779084600 @default.
• W2320153362 hasConcept C2779768347 @default.
• W2320153362 hasConcept C2780561956 @default.
• W2320153362 hasConcept C2780648677 @default.
• W2320153362 hasConcept C2780745239 @default.
• W2320153362 hasConcept C55493867 @default.
• W2320153362 hasConcept C555293320 @default.
• W2320153362 hasConcept C71924100 @default.
• W2320153362 hasConcept C86803240 @default.
• W2320153362 hasConceptScore W2320153362C12554922 @default.
• W2320153362 hasConceptScore W2320153362C126322002 @default.
• W2320153362 hasConceptScore W2320153362C134018914 @default.
• W2320153362 hasConceptScore W2320153362C170493617 @default.
• W2320153362 hasConceptScore W2320153362C184235292 @default.
• W2320153362 hasConceptScore W2320153362C185592680 @default.
• W2320153362 hasConceptScore W2320153362C195794163 @default.
• W2320153362 hasConceptScore W2320153362C24998067 @default.
• W2320153362 hasConceptScore W2320153362C2775984225 @default.
• W2320153362 hasConceptScore W2320153362C2776885963 @default.
• W2320153362 hasConceptScore W2320153362C2778902376 @default.
• W2320153362 hasConceptScore W2320153362C2778938600 @default.
• W2320153362 hasConceptScore W2320153362C2779084600 @default.
• W2320153362 hasConceptScore W2320153362C2779768347 @default.
• W2320153362 hasConceptScore W2320153362C2780561956 @default.
• W2320153362 hasConceptScore W2320153362C2780648677 @default.
• W2320153362 hasConceptScore W2320153362C2780745239 @default.
• W2320153362 hasConceptScore W2320153362C55493867 @default.
• W2320153362 hasConceptScore W2320153362C555293320 @default.
• W2320153362 hasConceptScore W2320153362C71924100 @default.
• W2320153362 hasConceptScore W2320153362C86803240 @default.
• W2320153362 hasIssue "6" @default.
• W2320153362 hasLocation W23201533621 @default.
• W2320153362 hasLocation W23201533622 @default.
• W2320153362 hasLocation W23201533623 @default.

• next