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- W2320187968 abstract "The synthesis of novel (ω-alkynyl-1-hydroxy-1,1-diyl)bisphosphonic acid tetramethyl esters (1a–c), their P,P′-dimethyl esters (2a–c), and two trimethyl ester derivatives (3a and 3b) is reported. The prepared compounds can be attached to many kinds of molecules containing azide (−N3) functionalities using a “click” chemistry approach. As an example, bisphosphonate trimethyl ester 3a and P,P′-dimethyl ester 2b were attached to triethylene glycol to form triethylene glycol–bisphosphonate conjugates 4 and 5 as model compounds for further studies in, for example, nanoparticle targeting." @default.
- W2320187968 created "2016-06-24" @default.
- W2320187968 creator A5026366549 @default.
- W2320187968 date "2014-06-19" @default.
- W2320187968 modified "2023-10-16" @default.
- W2320187968 title "Synthesis of Triple-Bond-Containing 1-Hydroxy-1,1-bisphosphonic Acid Derivatives To Be Used as Precursors in “Click” Chemistry: Two Examples" @default.
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- W2320187968 doi "https://doi.org/10.1021/jo500831r" @default.
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