FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320228714> ?p ?o ?g. }

• W2320228714 endingPage "25575" @default.
• W2320228714 startingPage "25558" @default.
• W2320228714 abstract "// Xuefei Shi 1, 3, * , Chenhui Ma 1, * , Qingqing Zhu 1 , Dongmei Yuan 1 , Ming Sun 2 , Xiaoling Gu 1 , Guannan Wu 1 , Tangfeng Lv 1 , Yong Song 1 1 Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China 2 Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China 3 Department of Respiratory Medicine, Huzhou Central Hospital, Huzhou, China * These authors have contributed equally to this work Correspondence to: Tangfeng Lv, e-mail: bairoushui@163.com Yong Song, e-mail: yong_song6310@yahoo.com Keywords: linc00673, proliferation, LSD1, NCALD, NSCLC Received: December 14, 2015      Accepted: March 07, 2016      Published: March 24, 2016 ABSTRACT Despite improvements in diagnostics and treatment of non-small cell lung cancer (NSCLC), it remains the leading causes of cancer-related mortality worldwide. In more recent years, mutiple lines of evidence have highlighted long noncoding RNAs (lncRNAs) serve as novel class of regulators of cancer biological processes, including proliferation, apoptosis and metastasis. LncRNAs serve as a novel class of regulators of cancer biological processes in cancer, but little is known of their expression and potential functions in NSCLC. We identified an oncogene, linc00673, whose expression level was upregulated by bioinformatics analyses and qRT-PCR analyses in NSCLC. The effects of linc00673 on tumor progression were investigated in vitro and in vivo . Linc00673 knockdown significantly inhibited cell proliferation and colony-forming ability, and suppressed S-phase entry in vitro and shRNA linc00673 mediated knockdown significantly inhibit tumor growth in vivo , meanwhile, linc00673 overexpression increased tumor cell growth. Analysis of RNAseq data revealed linc00673 could modulate the transcription of a large amount of genes including oncogene and tumor suppressor gene, so we investigated the role and regulatory mechanism of linc00673 in NSCLC proliferation. Further mechanistic analyses indicated that the oncogenic activity of linc00673 is partially attributable to its repression of NCALD through association with the epigenetic repressor LSD1. Taken together, these findings suggested that linc00673 could play crucial role in NSCLC progression and might be a potential therapeutic target for patients with NSCLC." @default.
• W2320228714 created "2016-06-24" @default.
• W2320228714 creator A5005476467 @default.
• W2320228714 creator A5006631538 @default.
• W2320228714 creator A5013052796 @default.
• W2320228714 creator A5015152308 @default.
• W2320228714 creator A5036586518 @default.
• W2320228714 creator A5039039790 @default.
• W2320228714 creator A5047686585 @default.
• W2320228714 creator A5047751161 @default.
• W2320228714 creator A5059230193 @default.
• W2320228714 date "2016-03-24" @default.
• W2320228714 modified "2023-10-09" @default.
• W2320228714 title "Upregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell lung cancer" @default.
• W2320228714 cites W1531414226 @default.
• W2320228714 cites W1555951822 @default.
• W2320228714 cites W1864729394 @default.
• W2320228714 cites W1868198369 @default.
• W2320228714 cites W1964943230 @default.
• W2320228714 cites W1965027943 @default.
• W2320228714 cites W1966682365 @default.
• W2320228714 cites W1973779246 @default.
• W2320228714 cites W1988062399 @default.
• W2320228714 cites W1988078905 @default.
• W2320228714 cites W1990895545 @default.
• W2320228714 cites W1994504474 @default.
• W2320228714 cites W2001730700 @default.
• W2320228714 cites W2005253752 @default.
• W2320228714 cites W2015863218 @default.
• W2320228714 cites W2025150647 @default.
• W2320228714 cites W2027010998 @default.
• W2320228714 cites W2032183472 @default.
• W2320228714 cites W2052741109 @default.
• W2320228714 cites W2067768332 @default.
• W2320228714 cites W2068661954 @default.
• W2320228714 cites W2082399900 @default.
• W2320228714 cites W2087377443 @default.
• W2320228714 cites W2089168341 @default.
• W2320228714 cites W2090333443 @default.
• W2320228714 cites W2097413644 @default.
• W2320228714 cites W2100441605 @default.
• W2320228714 cites W2116587853 @default.
• W2320228714 cites W2118352309 @default.
• W2320228714 cites W2119094970 @default.
• W2320228714 cites W2121828161 @default.
• W2320228714 cites W2124433696 @default.
• W2320228714 cites W2126496132 @default.
• W2320228714 cites W2126504590 @default.
• W2320228714 cites W2128876691 @default.
• W2320228714 cites W2141831115 @default.
• W2320228714 cites W2146573461 @default.
• W2320228714 cites W2150695488 @default.
• W2320228714 cites W2153826038 @default.
• W2320228714 cites W2165050206 @default.
• W2320228714 cites W2168197710 @default.
• W2320228714 cites W2170552969 @default.
• W2320228714 cites W2566863750 @default.
• W2320228714 cites W3108750466 @default.
• W2320228714 cites W4212766227 @default.
• W2320228714 doi "https://doi.org/10.18632/oncotarget.8338" @default.
• W2320228714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5041926" @default.
• W2320228714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27027352" @default.
• W2320228714 hasPublicationYear "2016" @default.
• W2320228714 type Work @default.
• W2320228714 sameAs 2320228714 @default.
• W2320228714 citedByCount "59" @default.
• W2320228714 countsByYear W23202287142016 @default.
• W2320228714 countsByYear W23202287142017 @default.
• W2320228714 countsByYear W23202287142018 @default.
• W2320228714 countsByYear W23202287142019 @default.
• W2320228714 countsByYear W23202287142020 @default.
• W2320228714 countsByYear W23202287142021 @default.
• W2320228714 countsByYear W23202287142022 @default.
• W2320228714 countsByYear W23202287142023 @default.
• W2320228714 crossrefType "journal-article" @default.
• W2320228714 hasAuthorship W2320228714A5005476467 @default.
• W2320228714 hasAuthorship W2320228714A5006631538 @default.
• W2320228714 hasAuthorship W2320228714A5013052796 @default.
• W2320228714 hasAuthorship W2320228714A5015152308 @default.
• W2320228714 hasAuthorship W2320228714A5036586518 @default.
• W2320228714 hasAuthorship W2320228714A5039039790 @default.
• W2320228714 hasAuthorship W2320228714A5047686585 @default.
• W2320228714 hasAuthorship W2320228714A5047751161 @default.
• W2320228714 hasAuthorship W2320228714A5059230193 @default.
• W2320228714 hasBestOaLocation W23202287141 @default.
• W2320228714 hasConcept C104317684 @default.
• W2320228714 hasConcept C121608353 @default.
• W2320228714 hasConcept C126322002 @default.
• W2320228714 hasConcept C127561419 @default.
• W2320228714 hasConcept C143998085 @default.
• W2320228714 hasConcept C173396325 @default.
• W2320228714 hasConcept C190232843 @default.
• W2320228714 hasConcept C190283241 @default.
• W2320228714 hasConcept C2776256026 @default.
• W2320228714 hasConcept C2779013556 @default.
• W2320228714 hasConcept C2781018059 @default.
• W2320228714 hasConcept C29537977 @default.
• W2320228714 hasConcept C502942594 @default.

• next