Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320257124> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2320257124 endingPage "2787" @default.
- W2320257124 startingPage "2784" @default.
- W2320257124 abstract "The effects of two methods of preparing small unilamellar vesicles (SUV) (detergent removal or sonication) on their in vivo elimination and tissue distribution was investigated in rats. The SUV prepared by either method had the same size distribution and lipid composition (egg yolk phosphatidylcholine/cholesterol/dipalmitoyl phosphatidylethanolamine or palmitic acid=20/10/0.3, molar ratio). Three types of SUV made by either method were prrepared. These contained one of three different surface ligand-binding functional groups (N-hydroxysuccinimide ester of palmitic acid, NHSP; glutaraldehyde-phosphatidylethanolamine, GA-PE; N-[4-(p-maleimidophenyl)butyryl]phosphatidylethanolamine, MPB-PE). SUV prepared by detergent removal were eliminated slowly from the circulation, and exhibited a low liver uptake and little leakage of [3H]inulin. There was no significant difference in elimination of the NHSP-SUV, GA-SUV or MPB-SUV prepared by detergent removal and their tissue distribution was similar. In contrast, the sonicated SUV were eliminated from the circulation much more rapidly mainly by liver uptake. The leakage of [3H]inulin from sonicated SUV into urine was relatively large. When sonicated control-SUV were prepared in the presence of the antioxidant, α-tocopherol (α-T-SUV), which reduces lipid peroxidation during sonication, the α-T-SUV were eliminated slowly with only a low liver uptake. Our results indicate that the rapid elimination and greater liver uptake of sonicated SUV is partly due to lipid peroxidation during preparation. These findings have relevance to the use of liposomes as a drug delivery system." @default.
- W2320257124 created "2016-06-24" @default.
- W2320257124 creator A5025823804 @default.
- W2320257124 creator A5031345854 @default.
- W2320257124 creator A5035599394 @default.
- W2320257124 creator A5081831531 @default.
- W2320257124 date "1990-01-01" @default.
- W2320257124 modified "2023-10-17" @default.
- W2320257124 title "Effects of preparing and ligand-binding methods of small unilamellar liposomes on their blood elimination and tissue distribution in rats." @default.
- W2320257124 cites W1987016173 @default.
- W2320257124 doi "https://doi.org/10.1248/cpb.38.2784" @default.
- W2320257124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2076562" @default.
- W2320257124 hasPublicationYear "1990" @default.
- W2320257124 type Work @default.
- W2320257124 sameAs 2320257124 @default.
- W2320257124 citedByCount "4" @default.
- W2320257124 countsByYear W23202571242012 @default.
- W2320257124 crossrefType "journal-article" @default.
- W2320257124 hasAuthorship W2320257124A5025823804 @default.
- W2320257124 hasAuthorship W2320257124A5031345854 @default.
- W2320257124 hasAuthorship W2320257124A5035599394 @default.
- W2320257124 hasAuthorship W2320257124A5081831531 @default.
- W2320257124 hasBestOaLocation W23202571241 @default.
- W2320257124 hasConcept C104628117 @default.
- W2320257124 hasConcept C185154212 @default.
- W2320257124 hasConcept C185592680 @default.
- W2320257124 hasConcept C2776330855 @default.
- W2320257124 hasConcept C2778004101 @default.
- W2320257124 hasConcept C2778918659 @default.
- W2320257124 hasConcept C2780829032 @default.
- W2320257124 hasConcept C2781170229 @default.
- W2320257124 hasConcept C41625074 @default.
- W2320257124 hasConcept C43617362 @default.
- W2320257124 hasConcept C55493867 @default.
- W2320257124 hasConceptScore W2320257124C104628117 @default.
- W2320257124 hasConceptScore W2320257124C185154212 @default.
- W2320257124 hasConceptScore W2320257124C185592680 @default.
- W2320257124 hasConceptScore W2320257124C2776330855 @default.
- W2320257124 hasConceptScore W2320257124C2778004101 @default.
- W2320257124 hasConceptScore W2320257124C2778918659 @default.
- W2320257124 hasConceptScore W2320257124C2780829032 @default.
- W2320257124 hasConceptScore W2320257124C2781170229 @default.
- W2320257124 hasConceptScore W2320257124C41625074 @default.
- W2320257124 hasConceptScore W2320257124C43617362 @default.
- W2320257124 hasConceptScore W2320257124C55493867 @default.
- W2320257124 hasIssue "10" @default.
- W2320257124 hasLocation W23202571241 @default.
- W2320257124 hasLocation W23202571242 @default.
- W2320257124 hasOpenAccess W2320257124 @default.
- W2320257124 hasPrimaryLocation W23202571241 @default.
- W2320257124 hasRelatedWork W1989334803 @default.
- W2320257124 hasRelatedWork W2013289415 @default.
- W2320257124 hasRelatedWork W2060146483 @default.
- W2320257124 hasRelatedWork W2067248905 @default.
- W2320257124 hasRelatedWork W2073396018 @default.
- W2320257124 hasRelatedWork W2075094032 @default.
- W2320257124 hasRelatedWork W2090148718 @default.
- W2320257124 hasRelatedWork W2244418172 @default.
- W2320257124 hasRelatedWork W2413467403 @default.
- W2320257124 hasRelatedWork W950194781 @default.
- W2320257124 hasVolume "38" @default.
- W2320257124 isParatext "false" @default.
- W2320257124 isRetracted "false" @default.
- W2320257124 magId "2320257124" @default.
- W2320257124 workType "article" @default.