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- W2320280742 abstract "You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology V1 Apr 2016MP88-02 EXPRESSION OF FORKHEAD BOX P3 IN BLADDER CANCER CELLS MODULATES SENSITIVITY TO HISTONE DEACETYLASE INHIBITORS Kris Prado, Hanwei Zhang, and Arnold Chin Kris PradoKris Prado More articles by this author , Hanwei ZhangHanwei Zhang More articles by this author , and Arnold ChinArnold Chin More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2420AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Histone deacetylase (HDAC) inhibitors induce cell cycle arrest, apoptosis, and cellular differentiation. We have previously shown synergy with cisplatin preferentially against cancer stem cells in urothelial carcinoma of the bladder. Forkhead box P3 (Foxp3) is a critical transcription factor in immune regulation and also preferentially expressed in various epithelial cancers. Foxp3 forms complexes with histone acetylases and deacetylases, which may modulate their activity. The purpose of this study is to define the role of Foxp3 in modulating sensitivity to HDAC inhibitors. METHODS Foxp3 expression was analyzed via flow cytometry and qPCR in SW780, T24, and HT1376 bladder cancer cell lines treated with cisplatin as well as the HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid. Cell lines with stable overexpression of Foxp3 were analyzed for sensitivity to cisplatin and HDAC inhibitors by MTT assay. RESULTS Treatment of bladder cancer cell lines with HDAC inhibitors induces expression of Foxp3. Overexpression Foxp3 was associated with resistance to cisplatin treatment, however conferred sensitivity to HDAC inhibitors. CONCLUSIONS Foxp3 expression sensitizes bladder cancer cell lines to HDAC inhibitors. This suggests a novel role of Foxp3 as a prognostic marker for future clinical trials and therapeutic target for treatment of bladder cancer. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1129 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Kris Prado More articles by this author Hanwei Zhang More articles by this author Arnold Chin More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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- W2320280742 title "MP88-02 EXPRESSION OF FORKHEAD BOX P3 IN BLADDER CANCER CELLS MODULATES SENSITIVITY TO HISTONE DEACETYLASE INHIBITORS" @default.
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