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- W2320297782 abstract "Background: Although BK virus nephropathy (BKVN) is the most common viral infection that affects renal allografts with a prevalence of 1-9% on average 8-13 months after renal transplantation, there are several reports of BKVN presenting late after transplantation. Although current guidelines recommend quantitative PCR for surveillance, urinary decoy cell detection is a potentially cost-effective alternative. We present the outcomes from cross-sectional BKV surveillance using decoy cell detection for initial screening. Materials and methods: Cytological urine analysis was performed in 146 samples (92 male and 57 female) from kidney transplant recipients (n=146). To determine the incidence of viremia and viuria, we performed quantitative PCR on the urine samples with decoy cells. The urine samples were collected 1 to 242 months after transplantation. Results: Decoy cell positivity occurred in 25 of the 146 recipients (17.1%). Viremia was present in 3 recipients (2.1%), and viuria was detected in 7 recipients (4.8%). One recipient (0.68%) developed polyoma virus nephropathy. The incidence of decoy cell positivity (42.3%), BK viremia (7.6%), and BK viuria (23.0%) for the recipients within 12 months after renal transplantation (n=26) was remarkably higher than that for all the recipients. However, no recipients within 12 months after transplant developed polyoma virus nephropathy. Conclusion: Our data showed low sensitivity of plasma BKV DNA and polyoma virus nephropathy for recipients with decoy cell positivity, although decoy cell screening by urine cytology as well as BKV quantitative PCR detection are both significant methods. These results suggested that the clinical courses of kidney transplant recipients with decoy cell positivity should be carefully followed up, particularly for those with impaired graft function." @default.
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- W2320297782 date "2012-11-01" @default.
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- W2320297782 title "Clinical Significance of Urinary Cytology Monitoring for Detecting Polyoma BK Virus in Kidney Transplant Recipients in Japan" @default.
- W2320297782 doi "https://doi.org/10.1097/00007890-201211271-01677" @default.
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