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• W2320299729 abstract "To achieve high sensitivity for 19F MRI, a class of novel dendritic molecules with multiple pseudosymmetrical fluorines was designed and efficiently synthesized. Through iterative bromination and Williamson ether synthesis under mild conditions, a fluorinated dendrimer with 540 pseudosymmetrical fluorines was conveniently prepared without performing the group protection in a convergent way. The dendrimer is characterized by a strong 19F NMR peak and short relaxation times. Eventually, an appreciably enhanced 19F MRI at an extremely low concentration (18.5 μM) was achieved, which demonstrated the potential utility of such dendritic molecules in highly sensitive 19F MRI." @default.
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• W2320299729 date "2015-04-20" @default.
• W2320299729 modified "2023-10-14" @default.
• W2320299729 title "Design and Synthesis of Fluorinated Dendrimers for Sensitive ¹⁹F MRI" @default.
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• W2320299729 doi "https://doi.org/10.1021/acs.joc.5b00294" @default.
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