Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320303676> ?p ?o ?g. }
- W2320303676 endingPage "201" @default.
- W2320303676 startingPage "194" @default.
- W2320303676 abstract "Studies on populations at different ages have shown that after birth, the gastrointestinal (GI) microbiota composition keeps evolving, and this seems to occur especially in old age. Significant changes in GI microbiota composition in older subjects have been reported in relation to diet, drug use and the settings where the older subjects are living, that is, in community nursing homes or in a hospital. Moreover, changes in microbiota composition in the old age have been related to immunosenescence and inflammatory processes that are pathophysiological mechanisms involved in the pathways of frailty. Frailty is an age-related condition of increased vulnerability to stresses due to the impairment in multiple inter-related physiologic systems that are associated with an increased risk of adverse outcomes, such as falls, delirium, institutionalization, hospitalization and death. Preliminary data suggest that changes in microbiota composition may contribute to the variations in the biological, clinical, functional and psycho-social domains that occur in the frail older subjects. Multidimensional evaluation tools based on a Comprehensive Geriatric Assessment (CGA) have demonstrated to be useful in identifying and measuring the severity of frailty in older subjects. Thus, a CGA approach should be used more widely in clinical practice to evaluate the multidimensional effects potentially related to GI microbiota composition of the older subjects. Probiotics have been shown to be effective in restoring the microbiota changes of older subjects, promoting different aspects of health in elderly people as improving immune function and reducing inflammation. Whether modulation of GI microbiota composition, with multi-targeted interventions, could have an effect on the prevention of frailty remains to be further investigated in the perspective of improving the health status of frail ‘high risk' older individuals." @default.
- W2320303676 created "2016-06-24" @default.
- W2320303676 creator A5006537028 @default.
- W2320303676 creator A5013907113 @default.
- W2320303676 creator A5033982616 @default.
- W2320303676 creator A5061342272 @default.
- W2320303676 date "2016-01-01" @default.
- W2320303676 modified "2023-09-23" @default.
- W2320303676 title "Gastrointestinal Microbiota and Their Contribution to Healthy Aging" @default.
- W2320303676 cites W133197154 @default.
- W2320303676 cites W1482062287 @default.
- W2320303676 cites W1490861410 @default.
- W2320303676 cites W1586551630 @default.
- W2320303676 cites W171134882 @default.
- W2320303676 cites W1964953858 @default.
- W2320303676 cites W1965234985 @default.
- W2320303676 cites W1967653421 @default.
- W2320303676 cites W1972916053 @default.
- W2320303676 cites W1976544976 @default.
- W2320303676 cites W1987184081 @default.
- W2320303676 cites W1987782068 @default.
- W2320303676 cites W1991147524 @default.
- W2320303676 cites W1991521547 @default.
- W2320303676 cites W1994630863 @default.
- W2320303676 cites W1999536756 @default.
- W2320303676 cites W2000804003 @default.
- W2320303676 cites W2003099302 @default.
- W2320303676 cites W2004052167 @default.
- W2320303676 cites W2005258869 @default.
- W2320303676 cites W2006094712 @default.
- W2320303676 cites W2007288537 @default.
- W2320303676 cites W2009128230 @default.
- W2320303676 cites W2010055058 @default.
- W2320303676 cites W2012490955 @default.
- W2320303676 cites W2025399737 @default.
- W2320303676 cites W2025465669 @default.
- W2320303676 cites W2027042725 @default.
- W2320303676 cites W2030243507 @default.
- W2320303676 cites W2030500910 @default.
- W2320303676 cites W2037100900 @default.
- W2320303676 cites W2040840388 @default.
- W2320303676 cites W2042504875 @default.
- W2320303676 cites W2043442946 @default.
- W2320303676 cites W2048887584 @default.
- W2320303676 cites W2054059225 @default.
- W2320303676 cites W2064642161 @default.
- W2320303676 cites W2064794807 @default.
- W2320303676 cites W2065718767 @default.
- W2320303676 cites W2066745538 @default.
- W2320303676 cites W2070023120 @default.
- W2320303676 cites W2073237861 @default.
- W2320303676 cites W2080731526 @default.
- W2320303676 cites W2082402714 @default.
- W2320303676 cites W2082704291 @default.
- W2320303676 cites W2088170171 @default.
- W2320303676 cites W2091940949 @default.
- W2320303676 cites W2092722556 @default.
- W2320303676 cites W2092735731 @default.
- W2320303676 cites W2097937398 @default.
- W2320303676 cites W2100096695 @default.
- W2320303676 cites W2103784576 @default.
- W2320303676 cites W2109744701 @default.
- W2320303676 cites W2117867727 @default.
- W2320303676 cites W2126057926 @default.
- W2320303676 cites W2129130754 @default.
- W2320303676 cites W2133780455 @default.
- W2320303676 cites W2135025386 @default.
- W2320303676 cites W2137017420 @default.
- W2320303676 cites W2140993771 @default.
- W2320303676 cites W2142514031 @default.
- W2320303676 cites W2142709556 @default.
- W2320303676 cites W2143948480 @default.
- W2320303676 cites W2147010636 @default.
- W2320303676 cites W2152575922 @default.
- W2320303676 cites W2153176347 @default.
- W2320303676 cites W2158319235 @default.
- W2320303676 cites W2160210515 @default.
- W2320303676 cites W2161590746 @default.
- W2320303676 cites W2331616415 @default.
- W2320303676 doi "https://doi.org/10.1159/000443350" @default.
- W2320303676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27028130" @default.
- W2320303676 hasPublicationYear "2016" @default.
- W2320303676 type Work @default.
- W2320303676 sameAs 2320303676 @default.
- W2320303676 citedByCount "26" @default.
- W2320303676 countsByYear W23203036762016 @default.
- W2320303676 countsByYear W23203036762017 @default.
- W2320303676 countsByYear W23203036762018 @default.
- W2320303676 countsByYear W23203036762019 @default.
- W2320303676 countsByYear W23203036762020 @default.
- W2320303676 countsByYear W23203036762021 @default.
- W2320303676 countsByYear W23203036762023 @default.
- W2320303676 crossrefType "journal-article" @default.
- W2320303676 hasAuthorship W2320303676A5006537028 @default.
- W2320303676 hasAuthorship W2320303676A5013907113 @default.
- W2320303676 hasAuthorship W2320303676A5033982616 @default.
- W2320303676 hasAuthorship W2320303676A5061342272 @default.
- W2320303676 hasConcept C118552586 @default.