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- W2320316033 abstract "Disrupted-in-schizophrenia 1 (DISC1) is a promising susceptibility gene for major mental illness. Recent studies have implicated DISC1 in key neurodevelopmental processes, including neurite outgrowth, neuronal migration and proliferation. Here, we report that DISC1 regulates cell–cell and cell–matrix adhesion and neurite outgrowth. DISC1 overexpression increased expression of the adherence junction protein N-cadherin and enhanced cell–cell adhesion. The increased N-cadherin accumulated in the areas of cell–cell contact. DISC1 overexpression also enhanced cell–matrix adhesion by inducing expression of β1-integrin protein. In the presence of nerve growth factor (NGF), DISC1 overexpression increased β1-integrin expression at the cell membrane and growth cone. NGF-induced neurite extension was enhanced by DISC1, and anti-β1-integrin antibody reduced the neurite outgrowth of DISC1-overexpressing cells to the control level. Furthermore, DISC1 also regulated N-cadherin and β1-integrin expression at the cell membrane in primary neurons. We conclude that DISC1 regulates cell–cell adhesion and cell–matrix adhesion by regulating the expression of adhesion molecules." @default.
- W2320316033 created "2016-06-24" @default.
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- W2320316033 date "2010-05-18" @default.
- W2320316033 modified "2023-10-18" @default.
- W2320316033 title "DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth" @default.
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- W2320316033 doi "https://doi.org/10.1038/mp.2010.60" @default.
- W2320316033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20479754" @default.
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