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• W2320342824 abstract "Event Abstract Back to Event Differences in maternal behaviour following peri-, pre- and postnatal administration of morphine in the rat and its behavioural consequences in offspring. Melinda Sobor1, 2*, J. Timar1, K. Kiraly1, Zs Gyarmati1 and Zs Furst1, 3 1 Department of Pharmacology and Pharmacotherapy, Semmelweis University, Hungary 2 National Institute of Pharmacy, Hungary 3 HAS-SE, Neuropsychopharmacological Research Group, Hungary Objective: Aim of the present study was to examine whether the daily MO treatment during pregnancy alters the effects of MO on maternal behaviour during lactation and how it influences other effects of MO in the dams and offspring. Methods: Wistar female rats, from the day of mating, were treated daily with MO (10 mg/kg sc.) or saline (SAL) until delivery. Than dams were further divided into subgroups and the following groups were composed: SAL/SAL, SAL/MO, MO/SAL, MO/MO. Maternal behaviour and retrieval test was measured on PD 2;3 (early pospartum period) and PD 4;5;6;7 (later postpartum period) 30 min after daily treatment. MO (3 mg/kg) induced place preference was compared in offspring of SAL/MO and MO/SAL dams. In the other series of experiments naloxone (NX)-induced withdrawal, the antinociceptive and the conditioned place preference (CPP) inducing effect of MO was studied in the MO/MO dams and compared to SAL/SAL ones. Results: MO treatment resulted in statistically significant impairment of maternal behaviour, gestational exposure did not influence it. NX precipitated mild physical withdrawal symptoms in dams. The antinociceptive effect of MO decreased and the CPP inducing effect of MO increasde in MO/MO dams. and also in offspring exposed to MO prenatally. Conclusion: 1.) While continous low dose morphine treatment during pregnancy and lactation reduces the antinociceptive and enhances the CPP-inducing effect of MO both in the dams and in the offspring measured after withdrawal, it did not induce either tolerance or sensitization to.the effect of MO on maternal behaviour. 2. Prenatal MO exposure results in higher risk to abuse liability, than the postnatal one. Supported by Hungarian grants OTKA K-60999 and ETT-441/2006 Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Behavioural neuroscience Citation: Sobor M, Timar J, Kiraly K, Gyarmati Z and Furst Z (2009). Differences in maternal behaviour following peri-, pre- and postnatal administration of morphine in the rat and its behavioural consequences in offspring.. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.104 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2009; Published Online: 03 Mar 2009. * Correspondence: Melinda Sobor, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary, sobor.melinda@ogyi.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Melinda Sobor J. Timar K. Kiraly Zs Gyarmati Zs Furst Google Melinda Sobor J. Timar K. Kiraly Zs Gyarmati Zs Furst Google Scholar Melinda Sobor J. Timar K. Kiraly Zs Gyarmati Zs Furst PubMed Melinda Sobor J. Timar K. Kiraly Zs Gyarmati Zs Furst Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2320342824 title "Differences in maternal behaviour following peri-, pre- and postnatal administration of morphine in the rat and its behavioural consequences in offspring." @default.
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