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- W2320372215 endingPage "412" @default.
- W2320372215 startingPage "401" @default.
- W2320372215 abstract "The nature of the pathogenesis and of the prolonged immunity of whooping cough has not been clearly defined. The literature on Bordetella pertussis indicates that only the antigen that induces histamine sensitization, lymphocytosis, and other biological reactions in. mice is the cause of the harmful effects and prolonged immunity of whooping cough. This antigen has the general characteristics of bacterial protein exotoxins that cause the harmful effects of infectious diseases such as diphtheria and tetanus. It is proposed that this antigen, which is histamine-sensitizing, lymphocyte-leukocyte-promoting, and islets-activating (HSF-LPF-IAP), be designated pertussis toxin. Agglutinogen, hemagglutinin, and heat-labile (at 56 C) and heat-stable (at 100 C) toxins are no doubt interrelated with the immunologic and/or toxic reactions of whooping cough. It appears that the first defense against the disease is the antibody that prevents adhesion of the bacteria to the cilia of the respiratory epithelium and that the second defense is the antitoxin against pertussis toxin (HSF-LPF-IAP)." @default.
- W2320372215 created "2016-06-24" @default.
- W2320372215 creator A5040614642 @default.
- W2320372215 date "1979-05-01" @default.
- W2320372215 modified "2023-10-15" @default.
- W2320372215 title "Pertussis Toxin: The Cause of the Harmful Effects and Prolonged Immunity of Whooping Cough. A Hypothesis" @default.
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- W2320372215 doi "https://doi.org/10.1093/clinids/1.3.401" @default.
- W2320372215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/233166" @default.
- W2320372215 hasPublicationYear "1979" @default.
- W2320372215 type Work @default.