Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320375421> ?p ?o ?g. }
- W2320375421 endingPage "787" @default.
- W2320375421 startingPage "787" @default.
- W2320375421 abstract "Primary liver cancer is one of the commonest causes of death. Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancers. For patients with unresectable or metastatic HCC, conventional chemotherapy is of limited or no benefit. Sorafenib is the only systemic treatment to demonstrate a statistically significant but modest overall survival benefit, leading to an era of targeted agents. Many clinical trials of targeted drugs have been carried out with many more in progress. Some drugs like PTK787 showed potential benefits in the treatment of HCC. Despite these promising breakthroughs, patients with HCC still have a dismal prognosis. Recently, both a phase III trial of everolimus and a phase II clinical trial of trebananib failed to demonstrate effective antitumor activity in advanced HCC. Sorafenib still plays a pivotal role in advanced HCC, leading to further explorations to exert its maximum efficacy. Combinations targeted with chemotherapy or transarterial chemoembolization is now being tested and might bring about advances. New targeted agents such as mammalian target of rapamycin inhibitors are under investigation, as well as further exploration of the mechanism of hepatocarcinogenesis." @default.
- W2320375421 created "2016-06-24" @default.
- W2320375421 creator A5001027254 @default.
- W2320375421 creator A5068980434 @default.
- W2320375421 creator A5087809584 @default.
- W2320375421 date "2015-01-01" @default.
- W2320375421 modified "2023-09-24" @default.
- W2320375421 title "Chemotherapy and target therapy for hepatocellular carcinoma: New advances and challenges" @default.
- W2320375421 cites W1538245709 @default.
- W2320375421 cites W1546500689 @default.
- W2320375421 cites W1601002325 @default.
- W2320375421 cites W1834944463 @default.
- W2320375421 cites W1838206574 @default.
- W2320375421 cites W1868766650 @default.
- W2320375421 cites W1908430636 @default.
- W2320375421 cites W1965309017 @default.
- W2320375421 cites W1968209756 @default.
- W2320375421 cites W1971837077 @default.
- W2320375421 cites W1980446197 @default.
- W2320375421 cites W1981187143 @default.
- W2320375421 cites W1990026158 @default.
- W2320375421 cites W1990881151 @default.
- W2320375421 cites W1994193851 @default.
- W2320375421 cites W1995811009 @default.
- W2320375421 cites W1997533142 @default.
- W2320375421 cites W2010265466 @default.
- W2320375421 cites W2012222876 @default.
- W2320375421 cites W2012934859 @default.
- W2320375421 cites W2016094100 @default.
- W2320375421 cites W2016364458 @default.
- W2320375421 cites W2020002352 @default.
- W2320375421 cites W2020267062 @default.
- W2320375421 cites W2020509813 @default.
- W2320375421 cites W2021845028 @default.
- W2320375421 cites W2022665891 @default.
- W2320375421 cites W2025572630 @default.
- W2320375421 cites W2033957860 @default.
- W2320375421 cites W2035747243 @default.
- W2320375421 cites W2037819581 @default.
- W2320375421 cites W2042407976 @default.
- W2320375421 cites W2046000826 @default.
- W2320375421 cites W2051684210 @default.
- W2320375421 cites W2052552898 @default.
- W2320375421 cites W2070686081 @default.
- W2320375421 cites W2074874299 @default.
- W2320375421 cites W2080663543 @default.
- W2320375421 cites W2080931115 @default.
- W2320375421 cites W2089756110 @default.
- W2320375421 cites W2092759077 @default.
- W2320375421 cites W2093538839 @default.
- W2320375421 cites W2101031676 @default.
- W2320375421 cites W2101459399 @default.
- W2320375421 cites W2101624426 @default.
- W2320375421 cites W2106036268 @default.
- W2320375421 cites W2109746877 @default.
- W2320375421 cites W2112489161 @default.
- W2320375421 cites W2113222623 @default.
- W2320375421 cites W2113686775 @default.
- W2320375421 cites W2114012800 @default.
- W2320375421 cites W2115497785 @default.
- W2320375421 cites W2116922255 @default.
- W2320375421 cites W2118471405 @default.
- W2320375421 cites W2119242310 @default.
- W2320375421 cites W2120967735 @default.
- W2320375421 cites W2128965737 @default.
- W2320375421 cites W2130210996 @default.
- W2320375421 cites W2132395321 @default.
- W2320375421 cites W2133559579 @default.
- W2320375421 cites W2134138119 @default.
- W2320375421 cites W2138059780 @default.
- W2320375421 cites W2138405392 @default.
- W2320375421 cites W2138610774 @default.
- W2320375421 cites W2139073495 @default.
- W2320375421 cites W2139511378 @default.
- W2320375421 cites W2140587309 @default.
- W2320375421 cites W2140765540 @default.
- W2320375421 cites W2141203222 @default.
- W2320375421 cites W2142752401 @default.
- W2320375421 cites W2143737148 @default.
- W2320375421 cites W2145271725 @default.
- W2320375421 cites W2145803146 @default.
- W2320375421 cites W2147834058 @default.
- W2320375421 cites W2149170098 @default.
- W2320375421 cites W2149456801 @default.
- W2320375421 cites W2150115931 @default.
- W2320375421 cites W2156538729 @default.
- W2320375421 cites W2157535532 @default.
- W2320375421 cites W2158474413 @default.
- W2320375421 cites W2159112333 @default.
- W2320375421 cites W2162147795 @default.
- W2320375421 cites W2162242700 @default.
- W2320375421 cites W2165031760 @default.
- W2320375421 cites W2165901246 @default.
- W2320375421 cites W2166805191 @default.
- W2320375421 cites W2168997800 @default.
- W2320375421 cites W2170030318 @default.
- W2320375421 cites W2473185292 @default.
- W2320375421 cites W4211105405 @default.