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- W2320399864 abstract "An essential challenge in the development of nanosized metal organic framework (nanoMOF) materials in biomedicine is to develop a strategy to stabilize their supramolecular structure in biological media while being able to control drug encapsulation and release. We have developed a method to efficiently encapsulate topotecan (TPT, 1), an important cytotoxic drug, in biodegradable nanoMOFs. Once inside the pores, 1 monomers aggregate in a “ship in a bottle” fashion, thus filling practically all of the nanoMOFs’ available free volume and stabilizing their crystalline supramolecular structures. Highly efficient results have been found with the human pancreatic cell line PANC1, in contrast with free 1. We also demonstrate that one- and two-photon light irradiation emerges as a highly promising strategy to promote stimuli-dependent 1 release from the nanoMOFs, hence opening new standpoints for further developments in triggered drug delivery." @default.
- W2320399864 created "2016-06-24" @default.
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- W2320399864 date "2013-12-24" @default.
- W2320399864 modified "2023-09-30" @default.
- W2320399864 title "A “Ship in a Bottle” Strategy To Load a Hydrophilic Anticancer Drug in Porous Metal Organic Framework Nanoparticles: Efficient Encapsulation, Matrix Stabilization, and Photodelivery" @default.
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- W2320399864 doi "https://doi.org/10.1021/jm4017202" @default.
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