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- W2320419785 abstract "Detailed information is now available about the structure of the hepatitis B virus (HBV) genome and about that phase of virus replication that involves reverse transcription of a “pregenomic” RNA precursor molecule. More recent work has explored the possible role of extrahepatic sites of infection, the secretion of envelope and core proteins from infected cells, the role of virus replication in liver damage and production of ground glass hepatocytes, the possible mechanism whereby persistent HBV infection predisposes to development of hepatocellular carcinoma, and the theoretical basis for future design of antiviral drugs. Much of this current work has been facilitated by availability of (1) experimental models provided by animal hepadnaviruses (2) use of transgenic mice expressing various HBV gene products (3) new cell culture systems that support partial or complete virus replication following infection with complete virus or viral DNA." @default.
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- W2320419785 date "1990-01-01" @default.
- W2320419785 modified "2023-09-26" @default.
- W2320419785 title "Biology of hepatitis B virus" @default.
- W2320419785 doi "https://doi.org/10.1016/s0031-3025(16)36391-7" @default.
- W2320419785 hasPublicationYear "1990" @default.
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