FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320423786> ?p ?o ?g. }

• W2320423786 endingPage "1199" @default.
• W2320423786 startingPage "1192" @default.
• W2320423786 abstract "Background. Blood transfusion (BT) may elicit both harmful and beneficial immune responses against a subsequent organ graft. Immune parameters of a single, nonleukocyte-depleted BT were investigated in two groups: non-human leukocyte antigen (HLA)-sensitized recipients with a one-HLA-DR matched donor (protocolled BT [PBT]) and females with previous exposure to HLA alloantigens through pregnancy (donor-specific transfusion [DST]). Methods. Thirty-five percent of DST recipients and 9.5% of PBT recipients developed HLA antibodies after BT. Phenotypic and functional analyses were performed in pre-BT, 2 weeks post-BT, and more than 10 weeks post-BT samples (PBT: n=10; DST: n=14). Result. The number of donor-reactive interferon-γ–producing memory T cells increased 2 weeks post-BT, but only in the DST group, increased frequencies persisted beyond 10 weeks (P<0.004). In the DST recipients, the proportion of natural killer cells (CD3−CD56+) significantly increased after BT (P=0.01), whereas in PBT recipients, the proportion of regulatory T cells (CD4+CD25+Foxp3+CD127low) significantly increased at 2 weeks post-BT (P=0.039). Microarray analysis confirmed increased activity of genes involved in function of natural killer cells, T cells, and B cells in DST recipients and increased expression of immune regulatory genes (galectin-1, Foxo3a, and follistatin-like 3) in PBT recipients. Galectin-1 expression by quantitative polymerase chain reaction was significantly enhanced in peripheral blood cells after PBT (P<0.05). Conclusion. Decreased immune effector mechanisms combined with an increased immune regulatory cell signature after HLA-DR-matched BT in nonsensitized patients is in line with clinical observations of improved outcome of a subsequent graft. Previous sensitization, however, may lead to HLA antibody formation and prolonged donor-specific memory T-cell reactivity after BT." @default.
• W2320423786 created "2016-06-24" @default.
• W2320423786 creator A5009702648 @default.
• W2320423786 creator A5019013671 @default.
• W2320423786 creator A5021544227 @default.
• W2320423786 creator A5024694410 @default.
• W2320423786 creator A5045798654 @default.
• W2320423786 creator A5063205034 @default.
• W2320423786 creator A5065564105 @default.
• W2320423786 creator A5070689180 @default.
• W2320423786 date "2010-12-15" @default.
• W2320423786 modified "2023-09-24" @default.
• W2320423786 title "Differential Effect of Pretransplant Blood Transfusions on Immune Effector and Regulatory Compartments in HLA-Sensitized and Nonsensitized Recipients" @default.
• W2320423786 cites W1502597889 @default.
• W2320423786 cites W1624592617 @default.
• W2320423786 cites W1903200987 @default.
• W2320423786 cites W1963786929 @default.
• W2320423786 cites W1965121539 @default.
• W2320423786 cites W1976853389 @default.
• W2320423786 cites W1978039427 @default.
• W2320423786 cites W1984253491 @default.
• W2320423786 cites W1985563101 @default.
• W2320423786 cites W1998405797 @default.
• W2320423786 cites W2005765588 @default.
• W2320423786 cites W2012053835 @default.
• W2320423786 cites W2015277268 @default.
• W2320423786 cites W2020269918 @default.
• W2320423786 cites W2022687427 @default.
• W2320423786 cites W2023480611 @default.
• W2320423786 cites W2024445520 @default.
• W2320423786 cites W2026262705 @default.
• W2320423786 cites W2040548384 @default.
• W2320423786 cites W2043867382 @default.
• W2320423786 cites W2043988780 @default.
• W2320423786 cites W2046361773 @default.
• W2320423786 cites W2050065318 @default.
• W2320423786 cites W2055522356 @default.
• W2320423786 cites W2059724105 @default.
• W2320423786 cites W2062858581 @default.
• W2320423786 cites W2067674980 @default.
• W2320423786 cites W2076755200 @default.
• W2320423786 cites W2077238267 @default.
• W2320423786 cites W2081614368 @default.
• W2320423786 cites W2086840376 @default.
• W2320423786 cites W2086977536 @default.
• W2320423786 cites W2157672076 @default.
• W2320423786 cites W2158715209 @default.
• W2320423786 cites W2339911136 @default.
• W2320423786 cites W2340671971 @default.
• W2320423786 cites W38029400 @default.
• W2320423786 doi "https://doi.org/10.1097/tp.0b013e3181fa943d" @default.
• W2320423786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21166103" @default.
• W2320423786 hasPublicationYear "2010" @default.
• W2320423786 type Work @default.
• W2320423786 sameAs 2320423786 @default.
• W2320423786 citedByCount "18" @default.
• W2320423786 countsByYear W23204237862012 @default.
• W2320423786 countsByYear W23204237862013 @default.
• W2320423786 countsByYear W23204237862014 @default.
• W2320423786 countsByYear W23204237862016 @default.
• W2320423786 countsByYear W23204237862017 @default.
• W2320423786 countsByYear W23204237862018 @default.
• W2320423786 countsByYear W23204237862020 @default.
• W2320423786 countsByYear W23204237862021 @default.
• W2320423786 crossrefType "journal-article" @default.
• W2320423786 hasAuthorship W2320423786A5009702648 @default.
• W2320423786 hasAuthorship W2320423786A5019013671 @default.
• W2320423786 hasAuthorship W2320423786A5021544227 @default.
• W2320423786 hasAuthorship W2320423786A5024694410 @default.
• W2320423786 hasAuthorship W2320423786A5045798654 @default.
• W2320423786 hasAuthorship W2320423786A5063205034 @default.
• W2320423786 hasAuthorship W2320423786A5065564105 @default.
• W2320423786 hasAuthorship W2320423786A5070689180 @default.
• W2320423786 hasBestOaLocation W23204237861 @default.
• W2320423786 hasConcept C114684123 @default.
• W2320423786 hasConcept C147483822 @default.
• W2320423786 hasConcept C154317977 @default.
• W2320423786 hasConcept C159654299 @default.
• W2320423786 hasConcept C1621761 @default.
• W2320423786 hasConcept C167672396 @default.
• W2320423786 hasConcept C188280979 @default.
• W2320423786 hasConcept C202751555 @default.
• W2320423786 hasConcept C203014093 @default.
• W2320423786 hasConcept C2776090121 @default.
• W2320423786 hasConcept C2778296632 @default.
• W2320423786 hasConcept C2779234475 @default.
• W2320423786 hasConcept C2779727006 @default.
• W2320423786 hasConcept C39347974 @default.
• W2320423786 hasConcept C55493867 @default.
• W2320423786 hasConcept C71924100 @default.
• W2320423786 hasConcept C79484868 @default.
• W2320423786 hasConcept C86803240 @default.
• W2320423786 hasConcept C8891405 @default.
• W2320423786 hasConceptScore W2320423786C114684123 @default.
• W2320423786 hasConceptScore W2320423786C147483822 @default.
• W2320423786 hasConceptScore W2320423786C154317977 @default.
• W2320423786 hasConceptScore W2320423786C159654299 @default.
• W2320423786 hasConceptScore W2320423786C1621761 @default.

• next