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- W2320461785 abstract "The dynamics of photosensitized singlet oxygen generation in a DNA microenvironment were examined using the DNA-binding photosensitizers berberine and palmatine. These photosensitizers generate singlet oxygen only under interaction with DNA because the singlet excited state deactivates rapidly in a nonbinding environment. A kinetic study demonstrated the reaction process whereby singlet oxygen is generated through energy transfer from the triplet excited state of DNA-binding berberine (or palmatine) to molecular oxygen. The guanine-containing sequence of DNA slightly deactivated the singlet excited state of the photosensitizers, resulting in a decrease of the singlet oxygen yield. By the steric hindrance of the DNA strand, the rate constant of the singlet oxygen generation became smaller than that of the other water-soluble photosensitizer." @default.
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- W2320461785 date "2012-02-23" @default.
- W2320461785 modified "2023-09-28" @default.
- W2320461785 title "Dynamics of Singlet Oxygen Generation by DNA-Binding Photosensitizers" @default.
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- W2320461785 doi "https://doi.org/10.1021/jp300142e" @default.
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