FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320565472> ?p ?o ?g. }

• W2320565472 endingPage "1039" @default.
• W2320565472 startingPage "1034" @default.
• W2320565472 abstract "Objectives We have established rat models of pancreatic ductal adenocarcinoma (PDAC) in which expression of a human H-rasG12V or K-rasG12V oncogene regulated by the Cre/lox system drives pancreatic carcinogenesis. Pancreatic ductal adenocarcinoma which develops in H-rasG12V and K-rasG12V transgenic rats is cytogenetically and histopathologically similar to human PDAC. The present study was designed to determine the feasibility of using the commercially available H-rasG12V transgenic rat to find diagnostic protein biomarkers for human pancreatic cancer. Methods For an animal model to be useful for searching for protein biomarkers for a disease, it is essential that proteins that are up-regulated in the model are also up-regulated in humans. We used liquid chromatography-tandem mass spectrometry (LC-MS/MS) to compare H-rasG12V transgenic rat PDAC with surrounding normal pancreas tissue. Results We identified 30 up-regulated proteins in the H-rasG12V transgenic rat PDAC lesions; importantly, 21 human homologs of these 30 rat proteins are up-regulated in human pancreatic cancer patients. Conclusions These results indicate that numerous proteins that are up-regulated in H—rasG12V transgenic rat PDAC are also up-regulated in human pancreatic cancer; therefore, this rat model can be used to search for diagnostic biomarkers for this disease." @default.
• W2320565472 created "2016-06-24" @default.
• W2320565472 creator A5004853249 @default.
• W2320565472 creator A5014399090 @default.
• W2320565472 creator A5014487965 @default.
• W2320565472 creator A5020821460 @default.
• W2320565472 creator A5022598500 @default.
• W2320565472 creator A5033542763 @default.
• W2320565472 creator A5043134802 @default.
• W2320565472 creator A5044475878 @default.
• W2320565472 creator A5048923727 @default.
• W2320565472 creator A5049816628 @default.
• W2320565472 creator A5057278746 @default.
• W2320565472 creator A5059912930 @default.
• W2320565472 creator A5079791444 @default.
• W2320565472 creator A5085745863 @default.
• W2320565472 creator A5091613702 @default.
• W2320565472 date "2013-08-01" @default.
• W2320565472 modified "2023-09-23" @default.
• W2320565472 title "Twenty-One Proteins Up-Regulated in Human H-ras Oncogene Transgenic Rat Pancreas Cancers are Up-Regulated in Human Pancreas Cancer" @default.
• W2320565472 cites W1991350055 @default.
• W2320565472 cites W2004407038 @default.
• W2320565472 cites W2004769917 @default.
• W2320565472 cites W2012924486 @default.
• W2320565472 cites W2022797070 @default.
• W2320565472 cites W2022972245 @default.
• W2320565472 cites W2028786127 @default.
• W2320565472 cites W2038463702 @default.
• W2320565472 cites W2040604172 @default.
• W2320565472 cites W2043250740 @default.
• W2320565472 cites W2045356233 @default.
• W2320565472 cites W2061240200 @default.
• W2320565472 cites W2065673022 @default.
• W2320565472 cites W2066135299 @default.
• W2320565472 cites W2074516923 @default.
• W2320565472 cites W2090502314 @default.
• W2320565472 cites W2090642125 @default.
• W2320565472 cites W2105805940 @default.
• W2320565472 cites W2106639175 @default.
• W2320565472 cites W2109694492 @default.
• W2320565472 cites W2114787622 @default.
• W2320565472 cites W2126663928 @default.
• W2320565472 cites W2134085863 @default.
• W2320565472 cites W2134527932 @default.
• W2320565472 cites W2152311737 @default.
• W2320565472 cites W2156250197 @default.
• W2320565472 cites W38552015 @default.
• W2320565472 doi "https://doi.org/10.1097/mpa.0b013e3182883624" @default.
• W2320565472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23648844" @default.
• W2320565472 hasPublicationYear "2013" @default.
• W2320565472 type Work @default.
• W2320565472 sameAs 2320565472 @default.
• W2320565472 citedByCount "5" @default.
• W2320565472 countsByYear W23205654722014 @default.
• W2320565472 countsByYear W23205654722015 @default.
• W2320565472 countsByYear W23205654722019 @default.
• W2320565472 crossrefType "journal-article" @default.
• W2320565472 hasAuthorship W2320565472A5004853249 @default.
• W2320565472 hasAuthorship W2320565472A5014399090 @default.
• W2320565472 hasAuthorship W2320565472A5014487965 @default.
• W2320565472 hasAuthorship W2320565472A5020821460 @default.
• W2320565472 hasAuthorship W2320565472A5022598500 @default.
• W2320565472 hasAuthorship W2320565472A5033542763 @default.
• W2320565472 hasAuthorship W2320565472A5043134802 @default.
• W2320565472 hasAuthorship W2320565472A5044475878 @default.
• W2320565472 hasAuthorship W2320565472A5048923727 @default.
• W2320565472 hasAuthorship W2320565472A5049816628 @default.
• W2320565472 hasAuthorship W2320565472A5057278746 @default.
• W2320565472 hasAuthorship W2320565472A5059912930 @default.
• W2320565472 hasAuthorship W2320565472A5079791444 @default.
• W2320565472 hasAuthorship W2320565472A5085745863 @default.
• W2320565472 hasAuthorship W2320565472A5091613702 @default.
• W2320565472 hasConcept C102230213 @default.
• W2320565472 hasConcept C104317684 @default.
• W2320565472 hasConcept C121608353 @default.
• W2320565472 hasConcept C126322002 @default.
• W2320565472 hasConcept C141035611 @default.
• W2320565472 hasConcept C142724271 @default.
• W2320565472 hasConcept C2778764654 @default.
• W2320565472 hasConcept C2780210213 @default.
• W2320565472 hasConcept C2781018059 @default.
• W2320565472 hasConcept C2781182431 @default.
• W2320565472 hasConcept C29537977 @default.
• W2320565472 hasConcept C502942594 @default.
• W2320565472 hasConcept C55493867 @default.
• W2320565472 hasConcept C555283112 @default.
• W2320565472 hasConcept C71924100 @default.
• W2320565472 hasConcept C86803240 @default.
• W2320565472 hasConceptScore W2320565472C102230213 @default.
• W2320565472 hasConceptScore W2320565472C104317684 @default.
• W2320565472 hasConceptScore W2320565472C121608353 @default.
• W2320565472 hasConceptScore W2320565472C126322002 @default.
• W2320565472 hasConceptScore W2320565472C141035611 @default.
• W2320565472 hasConceptScore W2320565472C142724271 @default.
• W2320565472 hasConceptScore W2320565472C2778764654 @default.
• W2320565472 hasConceptScore W2320565472C2780210213 @default.
• W2320565472 hasConceptScore W2320565472C2781018059 @default.
• W2320565472 hasConceptScore W2320565472C2781182431 @default.

• next