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- W2320586968 abstract "The cell surface substance prepared from Streptococcus mutans NCTC 10449 was used as immunogen, and its protective effect against dental caries was investigated in hamsters. The substance was administered with aluminium hydroxide subcutaneously two times before weaning. Hamsters immunized with this substance developed remarkably fewer caries on their molars than did hamsters sham-immunized, when challenged with S. mutans NCTC 10449. This preventive effect on caries development was associated with decreased recovery of bacteria from tooth surfaces, and saliva of immunized hamsters showed marked activity to inhibit adherence of S. mutans inoculated. These results suggest that the cell surface substance could be used as an effective immunogen against dental caries." @default.
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- W2320586968 date "1985-01-01" @default.
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- W2320586968 title "Effective immunity to dental caries by local immunization with cell surface substance extracted from Streptococcus mutans." @default.
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- W2320586968 doi "https://doi.org/10.5834/jdh.35.2" @default.
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