Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320605137> ?p ?o ?g. }
- W2320605137 endingPage "593" @default.
- W2320605137 startingPage "585" @default.
- W2320605137 abstract "Abstract Across a wide spectrum of cellular redox status, there emerges a dichotomy of responses in terms of cell survival/proliferation and cell death. Of note, there is emerging evidence that the anti-apoptotic protein, Bcl-2, in addition to its conventional activity of titrating the pro-apoptotic effects of proteins such as Bax and Bak at the mitochondria, also impacts cell fate decisions via modulating cellular redox metabolism. In this regard, both pro- and anti-oxidant effects of Bcl-2 overexpression have been described under different conditions and cellular contexts. In this short review, we attempt to analyze existing observations and present a probable explanation for the seemingly conflicting redox regulating activity of Bcl-2 from the standpoint of its pro-survival function. The consequential effect(s) of the dual redox functions of Bcl-2 are also discussed, particularly from the viewpoint of developing novel therapeutic strategies against cancers rendered refractory due to the aberrant expression of Bcl-2." @default.
- W2320605137 created "2016-06-24" @default.
- W2320605137 creator A5041865797 @default.
- W2320605137 creator A5063159222 @default.
- W2320605137 creator A5084717567 @default.
- W2320605137 date "2016-04-09" @default.
- W2320605137 modified "2023-09-23" @default.
- W2320605137 title "The anti-oxidant and pro-oxidant dichotomy of Bcl-2" @default.
- W2320605137 cites W1588232325 @default.
- W2320605137 cites W1595640022 @default.
- W2320605137 cites W1970834072 @default.
- W2320605137 cites W1972320300 @default.
- W2320605137 cites W1975813316 @default.
- W2320605137 cites W1979288446 @default.
- W2320605137 cites W1986742383 @default.
- W2320605137 cites W1990098630 @default.
- W2320605137 cites W1991013609 @default.
- W2320605137 cites W1991781635 @default.
- W2320605137 cites W1992806448 @default.
- W2320605137 cites W1993534135 @default.
- W2320605137 cites W1996400767 @default.
- W2320605137 cites W1997208169 @default.
- W2320605137 cites W1999197294 @default.
- W2320605137 cites W2000964442 @default.
- W2320605137 cites W2008898220 @default.
- W2320605137 cites W2009183786 @default.
- W2320605137 cites W2009219626 @default.
- W2320605137 cites W2009413686 @default.
- W2320605137 cites W2009479459 @default.
- W2320605137 cites W2013550947 @default.
- W2320605137 cites W2021051229 @default.
- W2320605137 cites W2024582476 @default.
- W2320605137 cites W2025695096 @default.
- W2320605137 cites W2027655179 @default.
- W2320605137 cites W2034269086 @default.
- W2320605137 cites W2034984756 @default.
- W2320605137 cites W2042254126 @default.
- W2320605137 cites W2044841933 @default.
- W2320605137 cites W2048580070 @default.
- W2320605137 cites W2049312704 @default.
- W2320605137 cites W2051122069 @default.
- W2320605137 cites W2052853635 @default.
- W2320605137 cites W2052864717 @default.
- W2320605137 cites W2063180308 @default.
- W2320605137 cites W2066571367 @default.
- W2320605137 cites W2069055691 @default.
- W2320605137 cites W2069531817 @default.
- W2320605137 cites W2069664359 @default.
- W2320605137 cites W2073164616 @default.
- W2320605137 cites W2081338918 @default.
- W2320605137 cites W2083031230 @default.
- W2320605137 cites W2086290282 @default.
- W2320605137 cites W2087687370 @default.
- W2320605137 cites W2090099409 @default.
- W2320605137 cites W2092003421 @default.
- W2320605137 cites W2092869304 @default.
- W2320605137 cites W2095236624 @default.
- W2320605137 cites W2099410111 @default.
- W2320605137 cites W2101061199 @default.
- W2320605137 cites W2102584757 @default.
- W2320605137 cites W2108049791 @default.
- W2320605137 cites W2110413857 @default.
- W2320605137 cites W2127868048 @default.
- W2320605137 cites W2132262469 @default.
- W2320605137 cites W2132403250 @default.
- W2320605137 cites W2133732014 @default.
- W2320605137 cites W2137289976 @default.
- W2320605137 cites W2139149064 @default.
- W2320605137 cites W2149065933 @default.
- W2320605137 cites W2149102487 @default.
- W2320605137 cites W2154921956 @default.
- W2320605137 cites W2155789124 @default.
- W2320605137 cites W2166788705 @default.
- W2320605137 cites W2167504781 @default.
- W2320605137 cites W2169979796 @default.
- W2320605137 cites W2170743452 @default.
- W2320605137 cites W2317926428 @default.
- W2320605137 cites W2319906419 @default.
- W2320605137 cites W2326077896 @default.
- W2320605137 doi "https://doi.org/10.1515/hsz-2016-0127" @default.
- W2320605137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27060742" @default.
- W2320605137 hasPublicationYear "2016" @default.
- W2320605137 type Work @default.
- W2320605137 sameAs 2320605137 @default.
- W2320605137 citedByCount "8" @default.
- W2320605137 countsByYear W23206051372017 @default.
- W2320605137 countsByYear W23206051372018 @default.
- W2320605137 countsByYear W23206051372020 @default.
- W2320605137 countsByYear W23206051372022 @default.
- W2320605137 countsByYear W23206051372023 @default.
- W2320605137 crossrefType "journal-article" @default.
- W2320605137 hasAuthorship W2320605137A5041865797 @default.
- W2320605137 hasAuthorship W2320605137A5063159222 @default.
- W2320605137 hasAuthorship W2320605137A5084717567 @default.
- W2320605137 hasConcept C104317684 @default.
- W2320605137 hasConcept C14036430 @default.
- W2320605137 hasConcept C1491633281 @default.
- W2320605137 hasConcept C163952510 @default.