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- W2320752894 abstract "血清カルシウム (Ca) が12mg/dl以上の中等症ないし重症の高Ca血症をきたした肺癌患者の臨床病態とその予後について検討した. 対象: 1990年8月～1998年4月の入院肺癌症例1126例のうち高Ca血症を呈した43例 (頻度3.8%).結果: 組織型は扁平上皮癌23例 (7.4%), 大細胞癌3例 (6.3%), 腺癌14例 (2.4%), 小細胞癌3例 (2.0%) で, 扁平上皮癌に多かった (p<0.0001). 臨床病期はIII期8例 (18%), IV期35例 (82%) であった. 高Ca血症の原因は主にPTHrPで, 血中レベルは測定39例中, 28例 (72%) に上昇した. 全症例の中間生存期間は47±28日で, 骨吸収抑制剤のビスホスホネート投与例 (19例) は58±26日で非投与例 (24例) の20±7日に比べ良好であった (p=0.0484). 多変量解析から高Ca血症例の予後不良因子は低アルブミン血症とperfomlancestatusの不良であった.結論: 肺癌での高Ca血症の頻度は3.8%で扁平上皮癌に多く, III期, IV期に発症した. 原因物質は主にPTHrPで予後は極めて不良であった." @default.
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- W2320752894 date "1999-01-01" @default.
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- W2320752894 title "Clinical Characteristics of Lung Cancer Patients with Moderate or Severe Hypercalcemia." @default.
- W2320752894 doi "https://doi.org/10.2482/haigan.39.429" @default.
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