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• W2320764148 abstract "To establish efficacy of vagus nerve stimulation (VNS) therapy in the treatment of intractable epilepsy, wecompared outcome data from the baseline period to the maintenance period (7 to 24 months post-implant) bycalculating the mean seizure frequency at 6-month intervals (7 to 12 months - first study period, 13 to 18 months -second study period, and 19 to 24 months - third study period), in 39 consecutive patients on unchanged antiepilepsydrug (AED) regimen for 24 months following the VNS implant. Of the 39 patients24 (61.5%) at first studyperiod, 25 (64.1 %) at second study period and 25 (64.1 %) at third study period were responders (≥50% reductionin seizures). Twenty one (53.9 %) patients were responders in all three study periods. Incremental seizure controlwas seen in 15 of these 21 patients. Although 3 (7.7%), 4 (10.3 %) and 8 (20.5%) patients had a total (100%)seizure control at first, second and third study periods respectively, no patient remained seizure-free through all 3study periods. Seven (17.9%) patients were partial responders (≥ 50% seizure reduction in two or less studyperiods). Eleven patients (28.2%) were non-responders (< 50% seizure reduction in all 3 study periods). Twentythree patients (59%) had partial epilepsy with and without secondarily generalization and 16 patients (41%) hadprimary generalized epilepsy. Eleven (47.8%) of the 23 patients with partial epilepsy and 10 (62.5%) of the 16patients with generalized epilepsy were responders in all three study periods. We conclude that: 1) More than 60 %of patients on unchanged AED regimen continued to be responders at 24 months following the VNS implant. 2) Atrend towards increasing responder rate with increasing duration of VNS therapy was observed.3) No majorcomplications or side effects requiring discontinuation of VNS therapy were noted." @default.
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• W2320764148 date "2014-01-01" @default.
• W2320764148 modified "2023-10-04" @default.
• W2320764148 title "Efficacy of Neuromodulation Therapy with Vagus Nerve Stimulator in Patients with Drug-Resistant Epilepsy on Unchanged Antiepileptic Medication Regimen for 24 Months Following the Implant" @default.
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• W2320764148 doi "https://doi.org/10.4172/2155-9562.1000268" @default.
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