FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320777188> ?p ?o ?g. }

• W2320777188 abstract "To determine to what extent urinary excretion of blood pressure-modulating electrolytes is genetically determined, and to identify their chromosomal localization.Twenty-six rat recombinant inbred strains (RIS) originating from reciprocal crosses of normotensive Brown Norway (BN.Lx) and spontaneously hypertensive rats (SHR) were used. A pilot experiment on a subset of strains determined that fasting decreases the impact of environmental noise and increases that of heritability. Twenty-four-hour urinary collections were obtained from fasting rats aged 6-12 weeks (3-8 rats per strain). Sodium (Na), potassium (K) and calcium (Ca) excretions were measured, and the Na/K ratio calculated. These phenotypes served as quantitative traits for the search of quantitative trait loci (QTLs) by scanning the RIS genome that was mapped with 475 polymorphic markers.Constant Na intake resulted in a low heritability for Na excretion, reflecting the environmental impact (intake = excretion), whereas fasting revealed a gradient among RIS indicative of the genetic component of the traits. In the fasting state, a locus on chromosome 14 was found to be significantly associated with K excretion (Alb, P = 0.00002, r = -0.69, logarithm of the odds score (LOD) 3.9), whereas another locus on chromosome 10 (D10Cebrp97s5, P = 0.0003, r = -0.69, LOD 3.0) and one on chromosome 6 (D6Cebrp97s14, P = 0.0007, r = -0.65, LOD 1.9) were more significantly associated with Na excretion and the Na/K ratio respectively. The observed correlations were all negative for Na, K and Na/K, indicating a higher excretion of Na and K and a greater Na/K ratio in rats bearing BN.Lx alleles at these loci, i.e. salt retention in fasting SHR. These three loci accounted for 47-55% of variance of their associated trait, suggesting that they are the main genetic determinants for these phenotypes in basal fasting conditions. Rats bearing the Y chromosome of SHR origin had significantly higher K excretion that, in turn, led to a significantly lower Na/K ratio. Finally, a locus on chromosome 7 was linked to Ca excretion, explaining 46% of the trait variance (D7Mit10, LOD score 3.0).RIS enabled us to determine QTLs for environmentally modulated traits such as Na, K and Ca excretions. We demonstrated that whereas urinary electrolytes are determined mainly by intake (environment) in a steady state, their excretion in an adaptive state (fasting) is predominantly genetically determined by distinct QTL on autosomes as well as the Y chromosome. Furthermore, the loci responsible for Na and K excretions act independently of the locus governing the relative excretion of Na/K. Thus, the salt-retaining aspects of some hypertensives may be, in large part, determined by genes responsible for renal excretion, the impact of which is predominant over the environment under acute challenge." @default.
• W2320777188 created "2016-06-24" @default.
• W2320777188 creator A5010839985 @default.
• W2320777188 creator A5012601206 @default.
• W2320777188 creator A5025572908 @default.
• W2320777188 creator A5033492851 @default.
• W2320777188 creator A5039985404 @default.
• W2320777188 creator A5052203036 @default.
• W2320777188 date "2002-02-01" @default.
• W2320777188 modified "2023-10-17" @default.
• W2320777188 title "Identification and chromosomal localization of ecogenetic components of electrolyte excretion" @default.
• W2320777188 cites W1481480932 @default.
• W2320777188 cites W1537463019 @default.
• W2320777188 cites W1975297178 @default.
• W2320777188 cites W1978290051 @default.
• W2320777188 cites W1980425497 @default.
• W2320777188 cites W1980957264 @default.
• W2320777188 cites W1994734908 @default.
• W2320777188 cites W1996791356 @default.
• W2320777188 cites W1998969154 @default.
• W2320777188 cites W2002038679 @default.
• W2320777188 cites W2002241222 @default.
• W2320777188 cites W2006302192 @default.
• W2320777188 cites W2017207920 @default.
• W2320777188 cites W2024262707 @default.
• W2320777188 cites W2024673992 @default.
• W2320777188 cites W2024959824 @default.
• W2320777188 cites W2027854295 @default.
• W2320777188 cites W2031190713 @default.
• W2320777188 cites W2032300827 @default.
• W2320777188 cites W2051106245 @default.
• W2320777188 cites W2060581518 @default.
• W2320777188 cites W2061613640 @default.
• W2320777188 cites W2065071701 @default.
• W2320777188 cites W2073881942 @default.
• W2320777188 cites W2088952971 @default.
• W2320777188 cites W2090690526 @default.
• W2320777188 cites W2093285783 @default.
• W2320777188 cites W2094732414 @default.
• W2320777188 cites W2095942814 @default.
• W2320777188 cites W2116619307 @default.
• W2320777188 cites W2123466824 @default.
• W2320777188 cites W2126470866 @default.
• W2320777188 cites W2128608719 @default.
• W2320777188 cites W2135213898 @default.
• W2320777188 cites W2140853270 @default.
• W2320777188 cites W2141052355 @default.
• W2320777188 cites W2144145018 @default.
• W2320777188 cites W2146061587 @default.
• W2320777188 cites W2152296620 @default.
• W2320777188 cites W2168624359 @default.
• W2320777188 cites W2293815785 @default.
• W2320777188 cites W2313309609 @default.
• W2320777188 cites W4231815062 @default.
• W2320777188 cites W4243990177 @default.
• W2320777188 cites W4250817533 @default.
• W2320777188 cites W4252899226 @default.
• W2320777188 cites W4254364732 @default.
• W2320777188 doi "https://doi.org/10.1097/00004872-200202000-00010" @default.
• W2320777188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11821705" @default.
• W2320777188 hasPublicationYear "2002" @default.
• W2320777188 type Work @default.
• W2320777188 sameAs 2320777188 @default.
• W2320777188 citedByCount "13" @default.
• W2320777188 countsByYear W23207771882012 @default.
• W2320777188 countsByYear W23207771882016 @default.
• W2320777188 crossrefType "journal-article" @default.
• W2320777188 hasAuthorship W2320777188A5010839985 @default.
• W2320777188 hasAuthorship W2320777188A5012601206 @default.
• W2320777188 hasAuthorship W2320777188A5025572908 @default.
• W2320777188 hasAuthorship W2320777188A5033492851 @default.
• W2320777188 hasAuthorship W2320777188A5039985404 @default.
• W2320777188 hasAuthorship W2320777188A5052203036 @default.
• W2320777188 hasConcept C10146269 @default.
• W2320777188 hasConcept C104317684 @default.
• W2320777188 hasConcept C126322002 @default.
• W2320777188 hasConcept C134018914 @default.
• W2320777188 hasConcept C161890455 @default.
• W2320777188 hasConcept C54355233 @default.
• W2320777188 hasConcept C71924100 @default.
• W2320777188 hasConcept C81941488 @default.
• W2320777188 hasConcept C84597430 @default.
• W2320777188 hasConcept C86803240 @default.
• W2320777188 hasConceptScore W2320777188C10146269 @default.
• W2320777188 hasConceptScore W2320777188C104317684 @default.
• W2320777188 hasConceptScore W2320777188C126322002 @default.
• W2320777188 hasConceptScore W2320777188C134018914 @default.
• W2320777188 hasConceptScore W2320777188C161890455 @default.
• W2320777188 hasConceptScore W2320777188C54355233 @default.
• W2320777188 hasConceptScore W2320777188C71924100 @default.
• W2320777188 hasConceptScore W2320777188C81941488 @default.
• W2320777188 hasConceptScore W2320777188C84597430 @default.
• W2320777188 hasConceptScore W2320777188C86803240 @default.
• W2320777188 hasLocation W23207771881 @default.
• W2320777188 hasLocation W23207771882 @default.
• W2320777188 hasOpenAccess W2320777188 @default.
• W2320777188 hasPrimaryLocation W23207771881 @default.
• W2320777188 hasRelatedWork W1966528946 @default.
• W2320777188 hasRelatedWork W1982723657 @default.
• W2320777188 hasRelatedWork W2023809354 @default.

• next