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- W2320778867 abstract "Biological systems have often to perform binary decisions under highly dynamic and noisy environments, such as during cell-fate determination. These decisions can be implemented by two main bifurcation mechanisms based on the transitions from either monostability or oscillation to bistability. We compare these two mechanisms by using stochastic models with time-varying fields and by establishing asymptotic formulas for the choice probabilities. Different scaling laws for decision sensitivity with respect to noise strength and signal timescale are obtained, supporting a role for oscillatory dynamics in performing noise-robust and temporally tunable binary decision-making. This result provides a rationale for recent experimental evidences showing that oscillatory expression of proteins often precedes binary cell-fate decisions." @default.
- W2320778867 created "2016-06-24" @default.
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- W2320778867 creator A5053417186 @default.
- W2320778867 date "2014-02-06" @default.
- W2320778867 modified "2023-09-30" @default.
- W2320778867 title "Reliable binary cell-fate decisions based on oscillations" @default.
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- W2320778867 doi "https://doi.org/10.1103/physreve.89.022707" @default.
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- W2320778867 hasPublicationYear "2014" @default.
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