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• W2320794248 abstract "5’1xc steroid-treuted putients with asthma were evaluated far the presence of muscle weakness $y USP of both manual muscle testing and the Cyhex II isokinetir dynamometer. The patients iiy’r(’ compared to uge und sex-matched sedentuy control subjects. Forty-eight percent of the putients (1 212.5) tuking 340 mg per day of prednisone had hip ,flexor strength 22 SD below the mean of. ugc tmd sex-mutched control subject.> by Cybex testing (CT). Sixb;four percent of the putienis ( 16125) taking 240 mg per day qf prednisone were found on munuul muscle testing :o have hip ,flexor weakness. OnI! one patient taking <30 mg per duy of prednisone was found to huvr~ muscle uwukrless. Biochemical parameters, including CPK, aldolase, SCOT. I.DH, and L.DH isoen~mes were measured to assess the degree of’ steroid-induced muscle damuge. They neither correlated with the degree of hip jlexor weakness us measured by CT, nor did they discriminate between patients receiving smull doses and large doses of steroids. !.‘hunge.c in tcrinury escretion of creutine did not help to co$rm the diagnosis qf steroid myopathy. Although CT provides an objective meun<s of assessing muscle strength in these putient.s, rtt this time no dejinitive chemical test is uvuilable ,fi7r tha diugno.sis qf steroid myoputh~. :.I ALLERGY CLIN ~MMUAQL 76.234-42. 1985. ) Muscle weakness associated with supraphysiologic levels cif corticosteroid hormones was first noted by Harvey Gushing in 1932.’ During the 1940s and i95Os. histologic changes were demonstrated in the rtn~scles~ oI steroid-treated animals. Soon thereafter. synthetic steroids came into use for the treatment of :+ wide variety of diseases. Large doses (by current standards) ‘were used. and Dubois’ and Freyberg & al.’ published articles in 1958 of muscle weakness in patlents as a result of the therapeutic administration &’ exogenous corticosteroids Fhe muscle changes and histology associated with steroid administration were described in animals and humans hi several investigators. Type IIB (fasttwitchi muscle fibers are most severely affected IV. experimental animals. However. because of the heterogeneous composition of human muscle, the Aangcx observed in patients are much less spe(“~ifiC,4 30 Why steroids cause characteristic pathologic L.hanges in muscle tissue and why they appear to affect AbbreLQutions rtsrd" @default.
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• W2320794248 date "1985-01-01" @default.
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• W2320794248 title ": Inctienw an,d detection in n with asthma" @default.
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