FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320797308> ?p ?o ?g. }

• W2320797308 endingPage "4469" @default.
• W2320797308 startingPage "4464" @default.
• W2320797308 abstract "Mulberry is a fruit containing polyphenol antioxidants. Cyclosporine (CSP), a potent immunosuppressant with a narrow therapeutic range, is widely used in transplant patients. This study investigated the effect of co-administration of mulberry on the bioavailability of CSP, a probe drug of P-glycoprotein (P-gp)/cytochrome P450 3A4 (CYP 3A4), in rats and relevant mechanisms. CSP (2.5 mg/kg) was orally administered with and without a single dose or the seventh dose of mulberry (2 g/kg) to rats. The results showed that a single dose of mulberry significantly decreased the area under the curve of concentration (AUC0–540) and the maximum blood concentration (Cmax) of CSP by 53.2 and 65.8%, respectively. Repeated dosing of mulberry significantly decreased the AUC0–540 and Cmax of CSP by 23.7 and 39.7%, respectively. Mechanism studies indicated that mulberry significantly increased the activities of P-gp and CYP 3A. In conclusion, mulberry significantly reduced the bioavailability of CSP through activating the functions of P-gp and CYP 3A." @default.
• W2320797308 created "2016-06-24" @default.
• W2320797308 creator A5003805332 @default.
• W2320797308 creator A5046417934 @default.
• W2320797308 creator A5047435191 @default.
• W2320797308 creator A5055657360 @default.
• W2320797308 creator A5059454915 @default.
• W2320797308 creator A5073324646 @default.
• W2320797308 date "2013-04-29" @default.
• W2320797308 modified "2023-10-16" @default.
• W2320797308 title "Potential Risk of Mulberry–Drug Interaction: Modulation on P-Glycoprotein and Cytochrome P450 3A" @default.
• W2320797308 cites W1966331166 @default.
• W2320797308 cites W1971101696 @default.
• W2320797308 cites W1977214587 @default.
• W2320797308 cites W1982897436 @default.
• W2320797308 cites W1995621981 @default.
• W2320797308 cites W1996607198 @default.
• W2320797308 cites W2001444572 @default.
• W2320797308 cites W2015500397 @default.
• W2320797308 cites W2021342556 @default.
• W2320797308 cites W2024511731 @default.
• W2320797308 cites W2033493930 @default.
• W2320797308 cites W2049365848 @default.
• W2320797308 cites W2053344338 @default.
• W2320797308 cites W2077736303 @default.
• W2320797308 cites W2078917293 @default.
• W2320797308 cites W2081967166 @default.
• W2320797308 cites W2084478052 @default.
• W2320797308 cites W2089886755 @default.
• W2320797308 cites W2090472200 @default.
• W2320797308 cites W2100882466 @default.
• W2320797308 cites W2102475188 @default.
• W2320797308 cites W2114042463 @default.
• W2320797308 cites W2114918609 @default.
• W2320797308 cites W2158030535 @default.
• W2320797308 cites W2163846228 @default.
• W2320797308 cites W2169949296 @default.
• W2320797308 doi "https://doi.org/10.1021/jf3052384" @default.
• W2320797308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23590720" @default.
• W2320797308 hasPublicationYear "2013" @default.
• W2320797308 type Work @default.
• W2320797308 sameAs 2320797308 @default.
• W2320797308 citedByCount "20" @default.
• W2320797308 countsByYear W23207973082014 @default.
• W2320797308 countsByYear W23207973082015 @default.
• W2320797308 countsByYear W23207973082016 @default.
• W2320797308 countsByYear W23207973082017 @default.
• W2320797308 countsByYear W23207973082018 @default.
• W2320797308 countsByYear W23207973082019 @default.
• W2320797308 countsByYear W23207973082020 @default.
• W2320797308 countsByYear W23207973082021 @default.
• W2320797308 countsByYear W23207973082022 @default.
• W2320797308 countsByYear W23207973082023 @default.
• W2320797308 crossrefType "journal-article" @default.
• W2320797308 hasAuthorship W2320797308A5003805332 @default.
• W2320797308 hasAuthorship W2320797308A5046417934 @default.
• W2320797308 hasAuthorship W2320797308A5047435191 @default.
• W2320797308 hasAuthorship W2320797308A5055657360 @default.
• W2320797308 hasAuthorship W2320797308A5059454915 @default.
• W2320797308 hasAuthorship W2320797308A5073324646 @default.
• W2320797308 hasConcept C109650736 @default.
• W2320797308 hasConcept C112705442 @default.
• W2320797308 hasConcept C133936738 @default.
• W2320797308 hasConcept C181389837 @default.
• W2320797308 hasConcept C185592680 @default.
• W2320797308 hasConcept C22979827 @default.
• W2320797308 hasConcept C2777288759 @default.
• W2320797308 hasConcept C2778707650 @default.
• W2320797308 hasConcept C2780035454 @default.
• W2320797308 hasConcept C501593827 @default.
• W2320797308 hasConcept C526171541 @default.
• W2320797308 hasConcept C55493867 @default.
• W2320797308 hasConcept C62231903 @default.
• W2320797308 hasConcept C71924100 @default.
• W2320797308 hasConcept C98274493 @default.
• W2320797308 hasConceptScore W2320797308C109650736 @default.
• W2320797308 hasConceptScore W2320797308C112705442 @default.
• W2320797308 hasConceptScore W2320797308C133936738 @default.
• W2320797308 hasConceptScore W2320797308C181389837 @default.
• W2320797308 hasConceptScore W2320797308C185592680 @default.
• W2320797308 hasConceptScore W2320797308C22979827 @default.
• W2320797308 hasConceptScore W2320797308C2777288759 @default.
• W2320797308 hasConceptScore W2320797308C2778707650 @default.
• W2320797308 hasConceptScore W2320797308C2780035454 @default.
• W2320797308 hasConceptScore W2320797308C501593827 @default.
• W2320797308 hasConceptScore W2320797308C526171541 @default.
• W2320797308 hasConceptScore W2320797308C55493867 @default.
• W2320797308 hasConceptScore W2320797308C62231903 @default.
• W2320797308 hasConceptScore W2320797308C71924100 @default.
• W2320797308 hasConceptScore W2320797308C98274493 @default.
• W2320797308 hasIssue "18" @default.
• W2320797308 hasLocation W23207973081 @default.
• W2320797308 hasLocation W23207973082 @default.
• W2320797308 hasOpenAccess W2320797308 @default.
• W2320797308 hasPrimaryLocation W23207973081 @default.
• W2320797308 hasRelatedWork W1969574919 @default.
• W2320797308 hasRelatedWork W2004325424 @default.
• W2320797308 hasRelatedWork W2030240071 @default.

• next