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- W2320804891 abstract "In the course of our screening program using a bleb-forming assay, a new inhibitor of protein kinase C (PKC) was found in the fermentation of a streptomycete. The inhibitor, RK-286C (4'-demethylamino-4'-hydroxystaurosporine), inhibited the morphological change of K562 cells, a human chronic erythroleukemia cell, induced by phorbol 12,13-dibutylate at the concentration of 3 microM. The same concentration of the compound inhibited the activity of PKC in vitro and the aggregation of rabbit platelets induced by collagen and arachidonic acid." @default.
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- W2320804891 title "A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine) I. Screening, taxonomy, fermentation and biological activity." @default.
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- W2320804891 doi "https://doi.org/10.7164/antibiotics.43.163" @default.
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