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- W2320834198 abstract "Neurons that produce neuropeptide Y have been implicated in the control of a variety of physiologic processes. This review specifically updates and reconsiders the large body of evidence supporting the idea that neuropeptide Y is also a key regulator of the reproductive hormone axis. Conventional pharmacologic approaches have been used in past studies to provide evidence that neuropeptide Y plays an important role in reproduction. In more recent investigations, however, gene-targeting approaches have also been used to re-examine these putative functions of neuropeptide Y. Pharmacologic studies of the reproductive effects of neuropeptide Y predicted that loss of the neuropeptide Y gene would cause an earlier initiation of puberty because of lack of inhibition of the hypothalamic-pituitary-gonadal axis, an increase in basal luteinizing hormone levels due to the loss of the inhibitory actions in a low steroid environment, a decrease in luteinizing hormone surge levels because of the absence of the facilitating effects of neuropeptide Y on proestrus, and consequent impairment of fertility. Surprisingly, only the anticipated diminution of the luteinizing hormone surge has been observed. The article discusses these findings and the limitations that apply to pharmacologic experiments, and interpretations of phenotypic changes that arise in genetically engineered mice." @default.
- W2320834198 created "2016-06-24" @default.
- W2320834198 creator A5014769599 @default.
- W2320834198 creator A5079360016 @default.
- W2320834198 creator A5086422466 @default.
- W2320834198 date "2002-06-01" @default.
- W2320834198 modified "2023-10-17" @default.
- W2320834198 title "Revisiting the reproductive functions of neuropeptide Y" @default.
- W2320834198 cites W1506723565 @default.
- W2320834198 cites W1546970785 @default.
- W2320834198 cites W1555861401 @default.
- W2320834198 cites W1669573844 @default.
- W2320834198 cites W1821976079 @default.
- W2320834198 cites W1965997524 @default.
- W2320834198 cites W1966464425 @default.
- W2320834198 cites W1967359474 @default.
- W2320834198 cites W1971607526 @default.
- W2320834198 cites W1972036696 @default.
- W2320834198 cites W1973341558 @default.
- W2320834198 cites W1974262562 @default.
- W2320834198 cites W1974368187 @default.
- W2320834198 cites W1977188111 @default.
- W2320834198 cites W1978672405 @default.
- W2320834198 cites W1979483810 @default.
- W2320834198 cites W1980233163 @default.
- W2320834198 cites W1980335383 @default.
- W2320834198 cites W1989267153 @default.
- W2320834198 cites W1990231037 @default.
- W2320834198 cites W1992380356 @default.
- W2320834198 cites W1993264929 @default.
- W2320834198 cites W1993990935 @default.
- W2320834198 cites W1995782992 @default.
- W2320834198 cites W1997289354 @default.
- W2320834198 cites W1998372148 @default.
- W2320834198 cites W2001095683 @default.
- W2320834198 cites W2001121427 @default.
- W2320834198 cites W2001660140 @default.
- W2320834198 cites W2002017388 @default.
- W2320834198 cites W2002294810 @default.
- W2320834198 cites W2005076467 @default.
- W2320834198 cites W2005275397 @default.
- W2320834198 cites W2005782659 @default.
- W2320834198 cites W2009981495 @default.
- W2320834198 cites W2010256902 @default.
- W2320834198 cites W2010680559 @default.
- W2320834198 cites W2011709649 @default.
- W2320834198 cites W2013306854 @default.
- W2320834198 cites W2014711623 @default.
- W2320834198 cites W2015879988 @default.
- W2320834198 cites W2017137915 @default.
- W2320834198 cites W2018168717 @default.
- W2320834198 cites W2024942055 @default.
- W2320834198 cites W2026265698 @default.
- W2320834198 cites W2029707852 @default.
- W2320834198 cites W2030366306 @default.
- W2320834198 cites W2035923958 @default.
- W2320834198 cites W2036216347 @default.
- W2320834198 cites W2036974412 @default.
- W2320834198 cites W2037339322 @default.
- W2320834198 cites W2038970416 @default.
- W2320834198 cites W2041710499 @default.
- W2320834198 cites W2042604118 @default.
- W2320834198 cites W2044069347 @default.
- W2320834198 cites W2047603278 @default.
- W2320834198 cites W2047780911 @default.
- W2320834198 cites W2051523199 @default.
- W2320834198 cites W2053700159 @default.
- W2320834198 cites W2053709527 @default.
- W2320834198 cites W2053807193 @default.
- W2320834198 cites W2054244592 @default.
- W2320834198 cites W2055205712 @default.
- W2320834198 cites W2055585185 @default.
- W2320834198 cites W2056087701 @default.
- W2320834198 cites W2056954967 @default.
- W2320834198 cites W2059669578 @default.
- W2320834198 cites W2061211669 @default.
- W2320834198 cites W2061505650 @default.
- W2320834198 cites W2061819194 @default.
- W2320834198 cites W2062073832 @default.
- W2320834198 cites W2064044397 @default.
- W2320834198 cites W2065112278 @default.
- W2320834198 cites W2065722350 @default.
- W2320834198 cites W2072147633 @default.
- W2320834198 cites W2075904895 @default.
- W2320834198 cites W2076655884 @default.
- W2320834198 cites W2076948215 @default.
- W2320834198 cites W2079295513 @default.
- W2320834198 cites W2080650027 @default.
- W2320834198 cites W2081072548 @default.
- W2320834198 cites W2082748472 @default.
- W2320834198 cites W2085136188 @default.
- W2320834198 cites W2086741106 @default.
- W2320834198 cites W2088269503 @default.
- W2320834198 cites W2088471064 @default.
- W2320834198 cites W2089475939 @default.
- W2320834198 cites W2090822048 @default.
- W2320834198 cites W2096796933 @default.
- W2320834198 cites W2099583536 @default.