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• W2320842015 abstract "8-Hydroxyquinolines (8HQ) have found widespread application in chemistry and biology due to their ability to complex a range of transition metal ions. The family of 2-substituted 8HQs has been proposed for use in the treatment of Alzheimer’s disease (AD). Most notably, the therapeutic PBT2 (Prana Biotechnology Ltd.) has been shown to act as an efficient metal chaperone, disaggregate metal-enriched amyloid plaques comprised of the Aβ peptide, inhibit Cu/Aβ redox chemistry, and reverse the AD phenotype in transgenic animal models. Yet surprisingly little is known about the molecular interactions at play. In this study, we show that the homologous ligand 2-[(dimethylamino)methyl]-8-hydroxyquinoline (HL) forms a CuL complex with a conditional (apparent) dissociation constant of 0.33 nM at pH 6.9 and is capable of forming ternary Cu2+ complexes with neurotransmitters including histamine (HA), glutamic acid (Glu), and glycine (Gly), with glutathione disulfide (GSSG), and with histidine (His) side chains of proteins and peptides including the Aβ peptide. Our findings suggest a molecular basis for the strong metal chaperone activity of PBT2, its ability to attenuate Cu2+/Aβ interactions, and its potential to promote neuroprotective and neuroregenerative effects." @default.
• W2320842015 created "2016-06-24" @default.
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• W2320842015 creator A5047385288 @default.
• W2320842015 date "2013-03-28" @default.
• W2320842015 modified "2023-10-17" @default.
• W2320842015 title "Mixed Ligand Cu²⁺ Complexes of a Model Therapeutic with Alzheimer’s Amyloid-β Peptide and Monoamine Neurotransmitters" @default.
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• W2320842015 cites W1945773664 @default.
• W2320842015 cites W1955466454 @default.
• W2320842015 cites W1964081428 @default.
• W2320842015 cites W1965194719 @default.
• W2320842015 cites W1965775076 @default.
• W2320842015 cites W1966029601 @default.
• W2320842015 cites W1970159001 @default.
• W2320842015 cites W1973818541 @default.
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• W2320842015 cites W1981839169 @default.
• W2320842015 cites W1985286385 @default.
• W2320842015 cites W1987928326 @default.
• W2320842015 cites W1999423193 @default.
• W2320842015 cites W2001994760 @default.
• W2320842015 cites W2002499460 @default.
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• W2320842015 cites W2021270810 @default.
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• W2320842015 cites W2040507364 @default.
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• W2320842015 cites W2045934933 @default.
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• W2320842015 doi "https://doi.org/10.1021/ic302289r" @default.
• W2320842015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23537393" @default.
• W2320842015 hasPublicationYear "2013" @default.
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