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- W2320846105 abstract "心筋電位依存性K+チャネルは心筋膜電位維持および活動電位保持に重要である.発現量の豊富なKv1.5とKv1.4チャネルの発現調節機構が検討された.Kv1.5遺伝子は上流域にcAMP応答配列 (CRE) が存在し心筋細胞内cAMP濃度上昇はKv1.5mRNA量を増加させた.この作用はOREを介し転写レベルで調節されていた.一方, 下垂体細胞ではcAMPはCREを介してmRNA量を減少させた.Kv1.4遺伝子はcAMPでは発現調節を受けず細胞内Ca2+上昇とPKO活性化によりmRNA量は増加した.Kv1.4とKv1.5は成長段階で異なる発現調節をうけていた.心肥大ではKv1.5mRNA量は著減しておりKv1.4mRNA量は増加していた.このようにKv1.4とKv1.5は同じShaker型K+チャネルに属するがその発現調節はまったく異なり病態心でのK+チャネルタンパクの構成は正常と異なる可能性が示唆された." @default.
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- W2320846105 date "1995-01-01" @default.
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- W2320846105 title "Regulation of voltage-gated potassium chanel geves in heart." @default.
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- W2320846105 doi "https://doi.org/10.5105/jse.15.130" @default.
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