Matches in SemOpenAlex for { <https://semopenalex.org/work/W2320888939> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2320888939 endingPage "e1" @default.
- W2320888939 startingPage "e1.179" @default.
- W2320888939 abstract "Semantic dementia (SD) is a unique syndrome in the frontotemporal lobar degeneration spectrum. Typically presenting as a progressive, fluent anomic aphasia, SD is the paradigmatic disorder of semantic memory with a characteristic anatomical profile of asymmetric, selective antero-inferior temporal lobe atrophy. Histopathologically, most cases show a specific pattern of abnormal deposition of protein TDP-43. This relatively close clinical, anatomical and pathological correspondence suggests SD as a promising target for future therapeutic trials. However, rational drug design and monitoring is likely to require a comprehensive understanding of how the molecular insult in SD translates to a clinico-anatomical phenotype. Here we propose a pathophysiological model of SD. The model is motivated by neuropsychological and neuroimaging data and posits the sequential, regionally determined disintegration of a vulnerable neural network. The key features of the model are: (1) existence of local zones of synaptic convergence within the temporal lobe with predictable network organisation; (2) a mechanism (or mechanisms) for transynaptic action of the molecular insult; and (3) establishment of a gradient of neuronal damage across the affected network, both within and between the temporal lobes. The model makes empirically testable predictions concerning the evolution of regional atrophy in SD." @default.
- W2320888939 created "2016-06-24" @default.
- W2320888939 creator A5004703049 @default.
- W2320888939 creator A5068675261 @default.
- W2320888939 date "2012-02-09" @default.
- W2320888939 modified "2023-09-23" @default.
- W2320888939 title "017 A network model of semantic dementia" @default.
- W2320888939 doi "https://doi.org/10.1136/jnnp-2011-301993.59" @default.
- W2320888939 hasPublicationYear "2012" @default.
- W2320888939 type Work @default.
- W2320888939 sameAs 2320888939 @default.
- W2320888939 citedByCount "0" @default.
- W2320888939 crossrefType "journal-article" @default.
- W2320888939 hasAuthorship W2320888939A5004703049 @default.
- W2320888939 hasAuthorship W2320888939A5068675261 @default.
- W2320888939 hasConcept C14216870 @default.
- W2320888939 hasConcept C142724271 @default.
- W2320888939 hasConcept C15744967 @default.
- W2320888939 hasConcept C169760540 @default.
- W2320888939 hasConcept C169900460 @default.
- W2320888939 hasConcept C180747234 @default.
- W2320888939 hasConcept C197914299 @default.
- W2320888939 hasConcept C207886595 @default.
- W2320888939 hasConcept C2776939681 @default.
- W2320888939 hasConcept C2778186239 @default.
- W2320888939 hasConcept C2778641062 @default.
- W2320888939 hasConcept C2779116556 @default.
- W2320888939 hasConcept C2779134260 @default.
- W2320888939 hasConcept C2779422653 @default.
- W2320888939 hasConcept C2779483572 @default.
- W2320888939 hasConcept C2781099131 @default.
- W2320888939 hasConcept C2781172350 @default.
- W2320888939 hasConcept C58693492 @default.
- W2320888939 hasConcept C71924100 @default.
- W2320888939 hasConceptScore W2320888939C14216870 @default.
- W2320888939 hasConceptScore W2320888939C142724271 @default.
- W2320888939 hasConceptScore W2320888939C15744967 @default.
- W2320888939 hasConceptScore W2320888939C169760540 @default.
- W2320888939 hasConceptScore W2320888939C169900460 @default.
- W2320888939 hasConceptScore W2320888939C180747234 @default.
- W2320888939 hasConceptScore W2320888939C197914299 @default.
- W2320888939 hasConceptScore W2320888939C207886595 @default.
- W2320888939 hasConceptScore W2320888939C2776939681 @default.
- W2320888939 hasConceptScore W2320888939C2778186239 @default.
- W2320888939 hasConceptScore W2320888939C2778641062 @default.
- W2320888939 hasConceptScore W2320888939C2779116556 @default.
- W2320888939 hasConceptScore W2320888939C2779134260 @default.
- W2320888939 hasConceptScore W2320888939C2779422653 @default.
- W2320888939 hasConceptScore W2320888939C2779483572 @default.
- W2320888939 hasConceptScore W2320888939C2781099131 @default.
- W2320888939 hasConceptScore W2320888939C2781172350 @default.
- W2320888939 hasConceptScore W2320888939C58693492 @default.
- W2320888939 hasConceptScore W2320888939C71924100 @default.
- W2320888939 hasIssue "3" @default.
- W2320888939 hasLocation W23208889391 @default.
- W2320888939 hasOpenAccess W2320888939 @default.
- W2320888939 hasPrimaryLocation W23208889391 @default.
- W2320888939 hasRelatedWork W1955960240 @default.
- W2320888939 hasRelatedWork W1967956494 @default.
- W2320888939 hasRelatedWork W2037435480 @default.
- W2320888939 hasRelatedWork W2040328682 @default.
- W2320888939 hasRelatedWork W2049075242 @default.
- W2320888939 hasRelatedWork W2167394014 @default.
- W2320888939 hasRelatedWork W2407057108 @default.
- W2320888939 hasRelatedWork W2989767837 @default.
- W2320888939 hasRelatedWork W3047205796 @default.
- W2320888939 hasRelatedWork W4376955522 @default.
- W2320888939 hasVolume "83" @default.
- W2320888939 isParatext "false" @default.
- W2320888939 isRetracted "false" @default.
- W2320888939 magId "2320888939" @default.
- W2320888939 workType "article" @default.