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- W2320935828 abstract "We assessed the endocrine function of 97 patients with myotonic dystrophy type 1 (DM1) nine years ago. The study identified several endocrine abnormalities, at a much higher prevalence than seen in the background population. The aim of this study was to re-investigate this cohort to characterize the temporal evolution of the endocrine dysfunction. At the time of re-evaluation, 19 from the original cohort had died. Nine patients were lost to follow-up, and 14 declined participation in the follow-up. Of the 55 remaining, 40 (19 males, 21 females) have been investigated so far. The endocrine function was assessed by measuring concentration of hormones in blood. Questionnaires were filled out to validate libido with the Female Sexual Function Index and the International Index of Erectile Function. At the time of the previous study, 17 of 40 patients investigated in this follow-up, presented with at least one hormonal dysfunction. Now, this number had increased to 31 of the 40 patients. Twenty-five % had either type 2 diabetes (3 patients) or impaired glucose tolerance (7 patients). None of these 10 patients had elevated glucose levels 9 years ago. The prevalence of diabetes and impaired glucose tolerance for Danish age-matched adults are 3.7% and 9.5%. Hyperparathyroidism was seen in 33% and abnormal TSH values in 20%, compared with 15% and 5% in the same patients 9 years ago. Ten of 19 men had increased LH levels compared with 5 in the previous study. In all patients, 33% had lowered levels of testosterone (16% of male and 48% of female patients). Libido was decreased in the female patients compared with healthy controls. The prevalence of endocrine abnormalities among patients with DM1 increases over time. Most important clinically, is the rising prevalence of impaired glucose tolerance and diabetes mellitus." @default.
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- W2320935828 date "2013-10-01" @default.
- W2320935828 modified "2023-09-27" @default.
- W2320935828 title "P.18.7 Endocrine function in patients with myotonic dystrophy type 1–9 year follow-up" @default.
- W2320935828 doi "https://doi.org/10.1016/j.nmd.2013.06.676" @default.
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