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• W2320968992 abstract "At first sight, the glomerular filter appears like a problem that should be easily solved. The majority of researchers view the filter like an impermeable wall perforated by specialized and size-selective pores (pore model). However, the fact that this model is in conflict with many of the experimental findings suggests that it may not yet be complete.In the more recent electrokinetic model, we have proposed including electrical effects (streaming potentials). The present review investigates how this can provide a relatively simple mechanistic explanation for the great majority of the so far unexplained characteristics of the filter, for example why the filter never clogs.Understanding how the glomerular filter functions is a prerequisite to investigate the pathogenesis of proteinuric glomerular diseases and the link between glomerular proteinuria and cardiovascular disease." @default.
• W2320968992 created "2016-06-24" @default.
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• W2320968992 date "2015-04-01" @default.
• W2320968992 modified "2023-10-01" @default.
• W2320968992 title "Progress and controversies in unraveling the glomerular filtration mechanism" @default.
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• W2320968992 doi "https://doi.org/10.1097/mnh.0000000000000116" @default.
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