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- W2321000256 abstract "Purpose of review Beyond their crucial role in host defence against invading pathogens, Toll-like receptors (TLRs) are now known to be key mediators of the ‘sterile’ innate immune response triggered by tissue injury. Here, we will review recent evidence examining the role of TLRs in determining the fate of the transplanted organ. Recent findings Experimental studies have delineated a crucial role for TLRs in the pathogenesis of ischaemia-reperfusion injury (IRI). Following transplantation, experimental models and observational human studies have confirmed TLRs as mediators of IRI but also suggest that TLRs modify the subsequent adaptive alloimmune response, which determines whether an organ is rejected or accepted. Summary As a key determinant of organ damage following ischaemia-reperfusion and as a modulator of the adaptive alloimmune response, we propose that TLR-mediated innate immune responses represent a potential therapeutic target to improve organ outcomes following transplantation." @default.
- W2321000256 created "2016-06-24" @default.
- W2321000256 creator A5073772726 @default.
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- W2321000256 date "2014-02-01" @default.
- W2321000256 modified "2023-10-14" @default.
- W2321000256 title "Roles of Toll-like receptors in transplantation" @default.
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- W2321000256 doi "https://doi.org/10.1097/mot.0000000000000038" @default.
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