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- W2321094032 endingPage "9962" @default.
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- W2321094032 abstract "Herein, we report the synthesis of 4'-C-aminomethyl-2'-deoxy-2'-fluorouridine, a therapeutically appealing RNA modification. Conformational analysis by DFT calculations and molecular dynamics simulations using trinucleotide model systems revealed that modified sugar adopts C3'-endo conformation. In this conformer, a weak intramolecular C-H···F H-bond between the hydrogen atom of the 4'-C-CH2 group and the F atom at the 2' position is observed. Comparative studies with unmodified, 2'-fluoro-, 2'-O-methyl-, and 4'-C-aminomethyl-2'-O-methyluridine showed the chemical nature of 2'-substituent dictates the sugar puckering of 2',4'-modified nucleotides." @default.
- W2321094032 created "2016-06-24" @default.
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- W2321094032 creator A5035166900 @default.
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- W2321094032 date "2013-09-24" @default.
- W2321094032 modified "2023-09-26" @default.
- W2321094032 title "Influence of 2′-Fluoro versus 2′-<i>O</i>-Methyl Substituent on the Sugar Puckering of 4′-<i>C</i>-Aminomethyluridine" @default.
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- W2321094032 doi "https://doi.org/10.1021/jo4012333" @default.
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