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- W2321151839 endingPage "201" @default.
- W2321151839 startingPage "201" @default.
- W2321151839 abstract "Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by the progressive loss of cholinergic neurons, leading to the onset of severe behavioral, motor and cognitive impairments. It is a pressing public health problem with no effective treatment. Existing therapies only provide symptomatic relief without being able to prevent, stop or reverse the pathologic process. While the molecular basis underlying this multifactorial neurodegenerative disorder remains a significant challenge, mitochondrial dysfunction appears to be a critical factor in the pathogenesis of this disease. It is therefore important to target mitochondrial dysfunction in the prodromal phase of AD to slow or prevent the neurodegenerative process and restore neuronal function. In this review, we discuss mechanisms of action and translational potential of current mitochondrial and bioenergetic therapeutics for AD including: mitochondrial enhancers to potentiate energy production; antioxidants to scavenge reactive oxygen species and reduce oxidative damage; glucose metabolism and substrate supply; and candidates that target apoptotic and mitophagy pathways to remove damaged mitochondria. While mitochondrial therapeutic strategies have shown promise at the preclinical stage, there has been little progress in clinical trials thus far." @default.
- W2321151839 created "2016-06-24" @default.
- W2321151839 creator A5029212864 @default.
- W2321151839 creator A5051601792 @default.
- W2321151839 creator A5059595648 @default.
- W2321151839 date "2016-01-01" @default.
- W2321151839 modified "2023-10-03" @default.
- W2321151839 title "Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies" @default.
- W2321151839 cites W1495825745 @default.
- W2321151839 cites W1511403368 @default.
- W2321151839 cites W1523693806 @default.
- W2321151839 cites W1527586649 @default.
- W2321151839 cites W1554017667 @default.
- W2321151839 cites W1650328097 @default.
- W2321151839 cites W1678800844 @default.
- W2321151839 cites W1867176171 @default.
- W2321151839 cites W1948763420 @default.
- W2321151839 cites W1965832173 @default.
- W2321151839 cites W1966191258 @default.
- W2321151839 cites W1966759922 @default.
- W2321151839 cites W1966762854 @default.
- W2321151839 cites W1967809393 @default.
- W2321151839 cites W1970637701 @default.
- W2321151839 cites W1975460873 @default.
- W2321151839 cites W1976779549 @default.
- W2321151839 cites W1979050144 @default.
- W2321151839 cites W1979526053 @default.
- W2321151839 cites W1980100638 @default.
- W2321151839 cites W1980114602 @default.
- W2321151839 cites W1981513091 @default.
- W2321151839 cites W1983761458 @default.
- W2321151839 cites W1985977889 @default.
- W2321151839 cites W1986399270 @default.
- W2321151839 cites W1989026904 @default.
- W2321151839 cites W1989305503 @default.
- W2321151839 cites W1989462226 @default.
- W2321151839 cites W1990990690 @default.
- W2321151839 cites W1991301011 @default.
- W2321151839 cites W1993160420 @default.
- W2321151839 cites W1996981671 @default.
- W2321151839 cites W2001315565 @default.
- W2321151839 cites W2001399124 @default.
- W2321151839 cites W2001534373 @default.
- W2321151839 cites W2004129180 @default.
- W2321151839 cites W2005425674 @default.
- W2321151839 cites W2005607645 @default.
- W2321151839 cites W2005910631 @default.
- W2321151839 cites W2006578754 @default.
- W2321151839 cites W2006909664 @default.
- W2321151839 cites W2009179699 @default.
- W2321151839 cites W2011480706 @default.
- W2321151839 cites W2011953782 @default.
- W2321151839 cites W2014918593 @default.
- W2321151839 cites W2015620326 @default.
- W2321151839 cites W2016602233 @default.
- W2321151839 cites W2017275974 @default.
- W2321151839 cites W2017741706 @default.
- W2321151839 cites W2020335617 @default.
- W2321151839 cites W2023402149 @default.
- W2321151839 cites W2023598683 @default.
- W2321151839 cites W2024233959 @default.
- W2321151839 cites W2025872915 @default.
- W2321151839 cites W2027395393 @default.
- W2321151839 cites W2028135614 @default.
- W2321151839 cites W2028220655 @default.
- W2321151839 cites W2031165402 @default.
- W2321151839 cites W2032814494 @default.
- W2321151839 cites W2034087770 @default.
- W2321151839 cites W2034201098 @default.
- W2321151839 cites W2035118435 @default.
- W2321151839 cites W2035815961 @default.
- W2321151839 cites W2036080646 @default.
- W2321151839 cites W2036573181 @default.
- W2321151839 cites W2038834667 @default.
- W2321151839 cites W2038976751 @default.
- W2321151839 cites W2039190163 @default.
- W2321151839 cites W2040856926 @default.
- W2321151839 cites W2041140784 @default.
- W2321151839 cites W2045838525 @default.
- W2321151839 cites W2049175236 @default.
- W2321151839 cites W2049865778 @default.
- W2321151839 cites W2051234759 @default.
- W2321151839 cites W2051490833 @default.
- W2321151839 cites W2052199849 @default.
- W2321151839 cites W2052674054 @default.
- W2321151839 cites W2055206622 @default.
- W2321151839 cites W2055378578 @default.
- W2321151839 cites W2055383351 @default.
- W2321151839 cites W2055820092 @default.
- W2321151839 cites W2056394193 @default.
- W2321151839 cites W2056673369 @default.
- W2321151839 cites W2058484936 @default.
- W2321151839 cites W2059009119 @default.
- W2321151839 cites W2059517195 @default.
- W2321151839 cites W2059543204 @default.
- W2321151839 cites W2063416493 @default.
- W2321151839 cites W2067805867 @default.
- W2321151839 cites W2068043241 @default.