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- W2321178085 abstract "The conjugation of a ribonucleic acid 16-mer with the cationic amphiphilic peptide penetratin and an anionic hyaluronan tetrasaccharide by means of Cu-free click chemistry is reported. The alkyne-functionalized 16-mer was prepared by automated solid-phase synthesis, using a newly developed strained cyclooctyne phosphoramidite in the final coupling. Cycloaddition of the alkyne functionalized RNA to the azide containing biomolecules led to a clean conversion into the corresponding nucleic acid conjugates." @default.
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- W2321178085 date "2010-11-04" @default.
- W2321178085 modified "2023-09-26" @default.
- W2321178085 title "Synthesis of Oligoribonucleic Acid Conjugates Using a Cyclooctyne Phosphoramidite" @default.
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- W2321178085 doi "https://doi.org/10.1021/ol102357u" @default.
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