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- W2321203497 abstract "Abstract Memory B cell responses are vital for protection against infections but must also be regulated to prevent autoimmunity. Cognate T cell help, somatic hypermutation, and affinity maturation within germinal centers (GCs) are required for high-affinity memory B cell formation; however, the signals that commit GC B cells to the memory pool remain unclear. In this study, we identify a role for IgG-immune complexes (ICs), FcγRs, and BAFF during the formation of memory B cells in mice. We found that early secretion of IgG in response to immunization with a T-dependent Ag leads to IC–FcγR interactions that induce dendritic cells to secrete BAFF, which acts at or upstream of Bcl-6 in activated B cells. Loss of CD16, hematopoietic cell–derived BAFF, or blocking IC:FcγR regions in vivo diminished the expression of Bcl-6, the frequency of GC and memory B cells, and secondary Ab responses. BAFF also contributed to the maintenance and/or expansion of the follicular helper T cell population, although it was dispensable for their formation. Thus, early Ab responses contribute to the optimal formation of B cell memory through IgG-ICs and BAFF. Our work defines a new role for FcγRs in GC and memory B cell responses." @default.
- W2321203497 created "2016-06-24" @default.
- W2321203497 creator A5003313372 @default.
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- W2321203497 creator A5068007837 @default.
- W2321203497 creator A5071645696 @default.
- W2321203497 date "2016-01-01" @default.
- W2321203497 modified "2023-09-29" @default.
- W2321203497 title "IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF" @default.
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