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- W2321253022 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCAlterations in TGFβ signaling have significant effects on tumor initiation and progression. TGFβ functions both as a tumor suppressor and as a tumor promoter. Most work so far to dissect mechanisms underlying this dual role of TGFβ has been largely focused on differential regulation of signaling pathways by tumor autonomous TGFβ signaling. Studies from our lab demonstrate that TGFβ significantly regulate inflammation in tumor microenvironment and host immune response. When TGFβ R2 receptor is deleted in mammary cancer epithelial cells, there was an increased inflammation and recruitment of Gr-1+CD11b+ myeloid cells, which leads to increased tumor invasion and metastasis. This infiltration of Gr-1+CD11b+ cells also results in increased abundance of TGFβ1 and metalloproteinase activity in tumors with Tgfbr2 deletion. Interestingly, Tumor-infiltrating Gr-1+CD11b+ cells exhibited significant elevated TGFs signaling including increased expression of RI and RII receptor, TGFs1 and TGFs3 ligands, as well as latent transforming growth factor s binding protein when compared with normal myeloid cells. Genetic deletion of Tgfbr2 in myeloid cells significantly attenuated 4T1 breast carcinoma tumor growth and metastasis. This is accompanied with significantly increased IFNγ production in the lungs of tumor bearing mice. These data suggest that TGFs, the tumor suppressor, also functions as an inflammation and immune suppressor. TGFs signaling in host derived myeloid cells is an important mediator in tumor immune surveillance. This new understanding of TGFs in inflammation and immune response in the interface of tumor and host may provide insight information for TGFs switch from a tumor suppressor to a tumor promoter.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1344." @default.
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- W2321253022 date "2010-04-15" @default.
- W2321253022 modified "2023-09-27" @default.
- W2321253022 title "Abstract 1344: TGFß, an inflammation and immune suppressor in tumor microenvironment and progression" @default.
- W2321253022 doi "https://doi.org/10.1158/1538-7445.am10-1344" @default.
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