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- W2321258366 abstract "While hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide, the signaling pathways involved are not fully understood and treatment of advanced disease still represents an area of high unmet medical need. We previously reported that IQ-motif-containing GTPase-activating-like proteins IQGAP1 and IQGAP2 play opposing roles in hepatic carcinogenesis. IQGAP2 was identified as a novel tumor suppressor linked to the Wnt/β-catenin signaling pathway in HCC. In this study, mouse embryonic fibroblasts (MEFs) isolated from Iqgap2−/- mice displayed higher proliferation and migration rates compared to wild-type MEFs as evident by MTT proliferation assay and wound healing assay. In contrast to HepG2, the SK-Hep1 and SNU387 HCC cell lines are characterized by low expression of IQGAP2 and relatively high levels of IQGAP1. Migration assay using blind well chambers with polycarbonate filters revealed 2-fold increased motility for both SK-Hep1 and SNU387 compared to HepG2 (p Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3989. doi:1538-7445.AM2012-3989" @default.
- W2321258366 created "2016-06-24" @default.
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- W2321258366 date "2012-04-15" @default.
- W2321258366 modified "2023-09-25" @default.
- W2321258366 title "Abstract 3989: IQGAP2 inhibits cell proliferation and migration in hepatocellular carcinoma" @default.
- W2321258366 doi "https://doi.org/10.1158/1538-7445.am2012-3989" @default.
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