Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321286968> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2321286968 abstract "αEβ7 (CD103), one of integrin family molecules, is a heterodimer consisting of an αE subunit and a β7 subunit. αEβ7 is expressed in several subsets of lymphocytes including T cells, intestinal intraepithelial lymphocytes and lamina propria lymphocytes. αEβ7 a ligand for E-cadherin, which is mainly expressed in epithelial cells, and an interaction between αEβ7 and E-cadherin results in adhesion of lymphocytes to epithelial cells. We found that EC5 domain, one of domains consisting E-cadherin, was indispensable for binding of E-cadherin with αEβ7. Accumulating evidence suggests that αEβ7 is not only involved in intestinal immune responses but also tissue damages associated with inflammatory diseases including autoimmune diseases. While E-cadherin is constitutively expressed in epithelial cells, the expression of αEβ7 is induced in T cells upon inflammatory stimulation in vitro. In addition, TGF-β1 induces the expression of αEβ7 via a pathway including Smad. These findings raise the possibility that αEβ7 is a potential therapeutic target for inflammatory diseases. We postulate that molecules that interfere with interaction between αEβ7 and E-cadherin are drug candidates for the diseases. We have been focusing on αEβ7 and vigorously investigating the mechanism that underlies the pathogenesis of autoimmune diseases." @default.
- W2321286968 created "2016-06-24" @default.
- W2321286968 creator A5040489632 @default.
- W2321286968 creator A5047228575 @default.
- W2321286968 creator A5064234962 @default.
- W2321286968 creator A5083314956 @default.
- W2321286968 date "2014-01-01" @default.
- W2321286968 modified "2023-09-25" @default.
- W2321286968 title "Involvement of αEβ7 (CD103) in the pathogenesis of autoimmune diseases" @default.
- W2321286968 cites W1556220620 @default.
- W2321286968 cites W1619186743 @default.
- W2321286968 cites W1923708602 @default.
- W2321286968 cites W1966593909 @default.
- W2321286968 cites W1966795465 @default.
- W2321286968 cites W1981651623 @default.
- W2321286968 cites W1981752846 @default.
- W2321286968 cites W1983435719 @default.
- W2321286968 cites W1985631934 @default.
- W2321286968 cites W1993531725 @default.
- W2321286968 cites W2002774826 @default.
- W2321286968 cites W2022556924 @default.
- W2321286968 cites W2025234475 @default.
- W2321286968 cites W2043205679 @default.
- W2321286968 cites W2043336677 @default.
- W2321286968 cites W2047278286 @default.
- W2321286968 cites W2047585875 @default.
- W2321286968 cites W2048060421 @default.
- W2321286968 cites W2059778210 @default.
- W2321286968 cites W2064496848 @default.
- W2321286968 cites W2072051141 @default.
- W2321286968 cites W2084457841 @default.
- W2321286968 cites W2103493503 @default.
- W2321286968 cites W2120492537 @default.
- W2321286968 cites W2121439103 @default.
- W2321286968 cites W2123349853 @default.
- W2321286968 cites W2123752399 @default.
- W2321286968 cites W2142838774 @default.
- W2321286968 cites W2168935492 @default.
- W2321286968 cites W2172184798 @default.
- W2321286968 cites W2417367631 @default.
- W2321286968 doi "https://doi.org/10.2177/jsci.37.171" @default.
- W2321286968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24974930" @default.
- W2321286968 hasPublicationYear "2014" @default.
- W2321286968 type Work @default.
- W2321286968 sameAs 2321286968 @default.
- W2321286968 citedByCount "1" @default.
- W2321286968 countsByYear W23212869682018 @default.
- W2321286968 crossrefType "journal-article" @default.
- W2321286968 hasAuthorship W2321286968A5040489632 @default.
- W2321286968 hasAuthorship W2321286968A5047228575 @default.
- W2321286968 hasAuthorship W2321286968A5064234962 @default.
- W2321286968 hasAuthorship W2321286968A5083314956 @default.
- W2321286968 hasBestOaLocation W23212869681 @default.
- W2321286968 hasConcept C1491633281 @default.
- W2321286968 hasConcept C149402561 @default.
- W2321286968 hasConcept C152605822 @default.
- W2321286968 hasConcept C16224149 @default.
- W2321286968 hasConcept C203014093 @default.
- W2321286968 hasConcept C2777310793 @default.
- W2321286968 hasConcept C2780942790 @default.
- W2321286968 hasConcept C529295009 @default.
- W2321286968 hasConcept C54355233 @default.
- W2321286968 hasConcept C86803240 @default.
- W2321286968 hasConcept C8891405 @default.
- W2321286968 hasConcept C95444343 @default.
- W2321286968 hasConceptScore W2321286968C1491633281 @default.
- W2321286968 hasConceptScore W2321286968C149402561 @default.
- W2321286968 hasConceptScore W2321286968C152605822 @default.
- W2321286968 hasConceptScore W2321286968C16224149 @default.
- W2321286968 hasConceptScore W2321286968C203014093 @default.
- W2321286968 hasConceptScore W2321286968C2777310793 @default.
- W2321286968 hasConceptScore W2321286968C2780942790 @default.
- W2321286968 hasConceptScore W2321286968C529295009 @default.
- W2321286968 hasConceptScore W2321286968C54355233 @default.
- W2321286968 hasConceptScore W2321286968C86803240 @default.
- W2321286968 hasConceptScore W2321286968C8891405 @default.
- W2321286968 hasConceptScore W2321286968C95444343 @default.
- W2321286968 hasLocation W23212869681 @default.
- W2321286968 hasLocation W23212869682 @default.
- W2321286968 hasOpenAccess W2321286968 @default.
- W2321286968 hasPrimaryLocation W23212869681 @default.
- W2321286968 hasRelatedWork W1985809672 @default.
- W2321286968 hasRelatedWork W1991326653 @default.
- W2321286968 hasRelatedWork W2040426958 @default.
- W2321286968 hasRelatedWork W2076775935 @default.
- W2321286968 hasRelatedWork W2096287500 @default.
- W2321286968 hasRelatedWork W2112945816 @default.
- W2321286968 hasRelatedWork W2321286968 @default.
- W2321286968 hasRelatedWork W2387261638 @default.
- W2321286968 hasRelatedWork W2409305065 @default.
- W2321286968 hasRelatedWork W3030458261 @default.
- W2321286968 isParatext "false" @default.
- W2321286968 isRetracted "false" @default.
- W2321286968 magId "2321286968" @default.
- W2321286968 workType "article" @default.