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• W2321305004 startingPage "713" @default.
• W2321305004 abstract "Oral contraceptives (OC) usage increases serum angiotensinogen levels to three to five times normal and about 5% of these women develop arterial hypertension. The genetic contribution to this susceptibility to OC-induced hypertension is poorly understood. We have analyzed the genotypes of 149 hypertensive and 101 normotensive women using oral contraceptives, for three genetic polymorphisms in genes of the renin-angiotensin system: an insertion/deletion (I/ D) in the angiotensin converting enzyme (ACE) gene, the T235M polymorphism of the angiotensinogen gene (AGT) and a point mutation in its promoter.After cessation of oral contraception the mean arterial pressures of the hypertensive women were separable into two non-overlapping groups; 88 of the women remained hypertensive and 61 returned to normal blood pressure. Both groups of hypertensive women had a similarly higher frequency of hypertensive relatives than the normotensive women, but were otherwise similar. The 235T allele of AGT was significantly increased in frequency in the 61 oral contraceptive-inducible hypertensive women compared with the controls and the 88 women that remained hypertensive. The ACE I/D genotypes were similarly distributed within the three groups of women, but were distinctly non-random in the oral contraceptive-induced hypertensive women when they were also classified by AGT genotype.This statistical interaction of genotype frequencies suggests that the genetic basis of susceptibility to OC-induced hypertension is complex." @default.
• W2321305004 created "2016-06-24" @default.
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• W2321305004 date "2001-04-01" @default.
• W2321305004 modified "2023-09-25" @default.
• W2321305004 title "Angiotensin-converting enzyme and angiotensinogen gene polymorphisms are non-randomly distributed in oral contraceptive-induced hypertension." @default.
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• W2321305004 doi "https://doi.org/10.1097/00004872-200104000-00008" @default.
• W2321305004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11330874" @default.
• W2321305004 hasPublicationYear "2001" @default.
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