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• W2321315411 abstract "Event Abstract Back to Event Galectin-3 regulates dendritic cell responses and hematopoietic cell mobilization during acute peritonitis induced by pristane Felipe Oliveira1*, Camila Brand1, Daniel Hsu2, Fu-Tong Liu2, Radovan Borojevic1, Roger Chammas3 and Márcia C. El-Cheikh1 1 Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Brazil 2 University of California, United States 3 Universidade de Sao Paulo, Brazil Galectin-3 adjusts cell-cell and cell-extracellular matrix interactions. We demonstrated that galectin-3 incites myeloid differentiation and inhibits B lymphocyte maturation in distinct lymphoid tissues. Here, we have investigated the role of galectin-3 in dendritic cell responses and hematopoietic cell mobilization during acute peritonitis. BALB/c (WT) and galectin-3-/- mice (gal-3-/-) intraperitoneally injected with pristane (immunologic adjuvant and plasmacytoma inducer) were studied 18h after the injection. Pristane induced a significant increase in peritoneal cellularity of WT and gal-3-/- mice, although it was observed 4-fold more cells in both mice. Cell cycle analysis of peritoneal cells of stimulated mice reinforced the recruitment hypothesis because 98.5% of WT cells and 98.8% of gal-3-/- cells were in G1 phase. Phenotypic and morphological analysis revealed that CD11b+Gr-1+ granulocytes and CD11b+/lowGr-1- monocytes were intensively mobilized to peritoneal cavity (PC) of WT mice and poorly mobilized in gal-3-/- mice, where the peritoneal exudate was essentially composed by mononuclear cells. Peritoneal CD4+CD8-B220- T lymphocytes and B220+CD19+CD4-CD8- B cells were indifferent to pristane, although there were 3-fold fewer B cells and reduced CD8+ T cells in control- and induced-gal-3-/- mice, respectively. Interestingly, peritoneal dendritic cells (DCs) showed distinct responses to pristane in the absence of galectin-3. Paradoxically, peritoneal CD11c+CD11b+ myeloid DCs were more evident in WT mice and B220+CD11c+CD11b- plasmacytoid DCs were widely detected in gal-3-/- mice after pristane-injection. The results suggested that galectin-3 regulates dendritic cell responses and hematopoietic cell-fate decisions during acute peritonitis induced by pristane. We considered galectin-3 as an important target to understand immune and inflammatory responses. Keywords: Galectin 3, B Cell Biology, Dendritic Cells, Peritoneum, antigen presenting cells Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Innate immunity Citation: Oliveira F, Brand C, Hsu D, Liu F, Borojevic R, Chammas R and El-Cheikh MC (2013). Galectin-3 regulates dendritic cell responses and hematopoietic cell mobilization during acute peritonitis induced by pristane. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00248 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Felipe Oliveira, Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Rio de Janeiro, Brazil, felipe@histo.ufrj.br Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Felipe Oliveira Camila Brand Daniel Hsu Fu-Tong Liu Radovan Borojevic Roger Chammas Márcia C El-Cheikh Google Felipe Oliveira Camila Brand Daniel Hsu Fu-Tong Liu Radovan Borojevic Roger Chammas Márcia C El-Cheikh Google Scholar Felipe Oliveira Camila Brand Daniel Hsu Fu-Tong Liu Radovan Borojevic Roger Chammas Márcia C El-Cheikh PubMed Felipe Oliveira Camila Brand Daniel Hsu Fu-Tong Liu Radovan Borojevic Roger Chammas Márcia C El-Cheikh Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2321315411 title "Galectin-3 regulates dendritic cell responses and hematopoietic cell mobilization during acute peritonitis induced by pristane" @default.
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