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- W2321330352 abstract "Abstract Boric acid, H 3 BO 3 , is a weak acid and at physiological pH is in the form of an uncharged small molecule. Behaving as a Lewis acid, it forms complexes with amino- and hydroxy acids, carbohydrates, nucleotides and vitamins through electron donor-acceptor interactions. These interactions are believed to be beneficial for human health. Synthetic bis- chelate complexes of boric acid with organic biomolecules are therefore considered for nutritional and/or pharmaceutical applications. The use of boric acid for BNCT has gained attention due to the short biological half-life, solubility, plasma circulation and the non-selective soft tissue accumulation properties of this simple molecule. Complexation of boric acid with sugars is of particular importance in understanding the role of boron as a carrier for nucleotides and carbohydrates. A potential and catalytic role of boric acid in peptide and nucleic acid synthesis and in the stabilization of sugar molecules by acting as a complexing agent have been demonstrated. Its possible role as a phosphorylation chaperone in a prebiotic world has been recently suggested. This contribution reviews the highlights in the physiologic, therapeutic and prebiotic significance of boric acid in the last decade." @default.
- W2321330352 created "2016-06-24" @default.
- W2321330352 creator A5021359368 @default.
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- W2321330352 date "2015-01-06" @default.
- W2321330352 modified "2023-10-11" @default.
- W2321330352 title "Boric acid: a simple molecule of physiologic, therapeutic and prebiotic significance" @default.
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- W2321330352 doi "https://doi.org/10.1515/pac-2014-0909" @default.
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