FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2321340265> ?p ?o ?g. }

• W2321340265 endingPage "140" @default.
• W2321340265 startingPage "140" @default.
• W2321340265 abstract "The exquisite sensitivity and frequency discrimination of mammalian hearing underlie the ability to understand complex speech in noise. This requires force generation by cochlear outer hair cells (OHCs) to amplify the basilar membrane traveling wave; however, it is unclear how amplification is achieved with sharp frequency tuning. Here we investigated the origin of tuning by measuring sound-induced 2-D vibrations within the mouse organ of Corti <i>in vivo</i>. Our goal was to determine the transfer function relating the radial shear between the structures that deflect the OHC bundle, the tectorial membrane and reticular lamina, to the transverse motion of the basilar membrane. We found that, after normalizing their responses to the vibration of the basilar membrane, the radial vibrations of the tectorial membrane and reticular lamina were tuned. The radial tuning peaked at a higher frequency than transverse basilar membrane tuning in the passive, postmortem condition. The radial tuning was similar in dead mice, indicating that this reflected passive, not active, mechanics. These findings were exaggerated in Tecta^{C1509G/C1509G} mice, where the tectorial membrane is detached from OHC stereocilia, arguing that the tuning of radial vibrations within the hair cell epithelium is distinct from tectorial membrane tuning. Together, these results reveal a passive, frequency-dependent contribution to cochlear filtering that is independent of basilar membrane filtering. These data argue that passive mechanics within the organ of Corti sharpen frequency selectivity by defining which OHCs enhance the vibration of the basilar membrane, thereby tuning the gain of cochlear amplification. <b>SIGNIFICANCE STATEMENT</b> Outer hair cells amplify the traveling wave within the mammalian cochlea. The resultant gain and frequency sharpening are necessary for speech discrimination, particularly in the presence of background noise. Here we measured the 2-D motion of the organ of Corti in mice and found that the structures that stimulate the outer hair cell stereocilia, the tectorial membrane and reticular lamina, were sharply tuned in the radial direction. Radial tuning was similar in dead mice and in mice lacking a tectorial membrane. This suggests that radial tuning comes from passive mechanics within the hair cell epithelium, and that these mechanics, at least in part, may tune the gain of cochlear amplification." @default.
• W2321340265 created "2016-06-24" @default.
• W2321340265 creator A5035579737 @default.
• W2321340265 date "1986-01-01" @default.
• W2321340265 modified "2023-09-26" @default.
• W2321340265 title "Phantom sensations: Is perceived body image congenital or acquired?" @default.
• W2321340265 doi "https://doi.org/10.1212/wnl.36.1.140" @default.
• W2321340265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3941778" @default.
• W2321340265 hasPublicationYear "1986" @default.
• W2321340265 type Work @default.
• W2321340265 sameAs 2321340265 @default.
• W2321340265 citedByCount "1" @default.
• W2321340265 crossrefType "journal-article" @default.
• W2321340265 hasAuthorship W2321340265A5035579737 @default.
• W2321340265 hasConcept C105702510 @default.
• W2321340265 hasConcept C121332964 @default.
• W2321340265 hasConcept C12554922 @default.
• W2321340265 hasConcept C192562407 @default.
• W2321340265 hasConcept C24890656 @default.
• W2321340265 hasConcept C2776557274 @default.
• W2321340265 hasConcept C2778500370 @default.
• W2321340265 hasConcept C2778585322 @default.
• W2321340265 hasConcept C2778969067 @default.
• W2321340265 hasConcept C2780130748 @default.
• W2321340265 hasConcept C2780659331 @default.
• W2321340265 hasConcept C2780807236 @default.
• W2321340265 hasConcept C2781459932 @default.
• W2321340265 hasConcept C86803240 @default.
• W2321340265 hasConcept C95190701 @default.
• W2321340265 hasConceptScore W2321340265C105702510 @default.
• W2321340265 hasConceptScore W2321340265C121332964 @default.
• W2321340265 hasConceptScore W2321340265C12554922 @default.
• W2321340265 hasConceptScore W2321340265C192562407 @default.
• W2321340265 hasConceptScore W2321340265C24890656 @default.
• W2321340265 hasConceptScore W2321340265C2776557274 @default.
• W2321340265 hasConceptScore W2321340265C2778500370 @default.
• W2321340265 hasConceptScore W2321340265C2778585322 @default.
• W2321340265 hasConceptScore W2321340265C2778969067 @default.
• W2321340265 hasConceptScore W2321340265C2780130748 @default.
• W2321340265 hasConceptScore W2321340265C2780659331 @default.
• W2321340265 hasConceptScore W2321340265C2780807236 @default.
• W2321340265 hasConceptScore W2321340265C2781459932 @default.
• W2321340265 hasConceptScore W2321340265C86803240 @default.
• W2321340265 hasConceptScore W2321340265C95190701 @default.
• W2321340265 hasIssue "1" @default.
• W2321340265 hasLocation W23213402651 @default.
• W2321340265 hasLocation W23213402652 @default.
• W2321340265 hasOpenAccess W2321340265 @default.
• W2321340265 hasPrimaryLocation W23213402651 @default.
• W2321340265 hasRelatedWork W1998759792 @default.
• W2321340265 hasRelatedWork W2003284917 @default.
• W2321340265 hasRelatedWork W2073137995 @default.
• W2321340265 hasRelatedWork W2146247758 @default.
• W2321340265 hasRelatedWork W2244278192 @default.
• W2321340265 hasRelatedWork W2346380599 @default.
• W2321340265 hasRelatedWork W2476266271 @default.
• W2321340265 hasRelatedWork W2784574675 @default.
• W2321340265 hasRelatedWork W3199767504 @default.
• W2321340265 hasRelatedWork W678261 @default.
• W2321340265 hasVolume "36" @default.
• W2321340265 isParatext "false" @default.
• W2321340265 isRetracted "false" @default.
• W2321340265 magId "2321340265" @default.
• W2321340265 workType "article" @default.